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- W4313344584 abstract "Abstract It has been shown that TGF-β signaling plays key roles in the induction of oral tolerance (OT). We assess the ability of CD4-dominant negative TGF-βRII (TbRII) mice to develop mucosal unresponsiveness to orally administered antigen to understand the role of TGF-β signaling in the early events of OT. Mice were fed a large dose (30 mg) of OVA and were orally immunized three times at weekly intervals with OVA (1mg) plus native cholera toxin (nCT) one week after tolerization. One week after last immunization plasma and fecal extract samples were collected and mononuclear cells were isolated from spleen, Peyer's Patches (PPs), and mesenteric lymph nodes for analysis by ELISA, ELISPOT and flow cytometry. DTH responses were determined by ear swelling after challenge with OVA. In order to examine the roles of TGF-β signaling in early events of OT induction, CD4+ T cells from C57BL/6 mice were examined for the expression of TGF-βR II at 24-hour intervals for 3 days and on days 5 and 7 after feeding 30mg OVA. OVA-specific IgG and S-IgA titers in plasma and fecal extracts, respectively, as well as DTH response of OVA-fed TbRII mice were essentially the same as TbRII mice fed PBS. These responses were significantly higher than those of C57BL/6 wildtype mice fed OVA. Expression of TGF-βRII by CD4+ T cells of spleen and MLN of wildtype mice was low or variable, respectively. In contrast, expression of TGF-βRII by PP CD4+ T cells was significantly increased over base-line beginning at 24 hours and continued to remain high one week after tolerization. These results indicate a critical role for TGF-β signaling in OT induction. Further, our findings may indicate important roles for the PPs in the initiation of mucosal unresponsiveness This work is supported by NIH grants DE 0176707, DE 012242 and AG 025873." @default.
- W4313344584 created "2023-01-06" @default.
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- W4313344584 date "2009-04-01" @default.
- W4313344584 modified "2023-10-03" @default.
- W4313344584 title "TGF-βRII expressing Peyer’s Patch CD4+ T cells are essential for the induction of mucosal unresponsiveness (39.49)" @default.
- W4313344584 doi "https://doi.org/10.4049/jimmunol.182.supp.39.49" @default.
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