Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313344595> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W4313344595 endingPage "45.27" @default.
- W4313344595 startingPage "45.27" @default.
- W4313344595 abstract "Abstract IFN-γ is crucial for protection against M. tuberculosis (Mtb). Previously we reported that signaling through SLAM on Mtb-stimulated cells induced CREB activation increasing IFN-γ. Here, we deeply investigated the potential relationship between SLAM-CREB and IFN-γ. After Mtb-stimulation, most of the IFN-γ+ cells co-expressed SLAM and pCREB (48,68 ± 11,18), whereas a smaller percentage of T cells expressed one of the two molecules. These results demonstrate that the induction of IFN-γ mediated by SLAM in TB depends, at least in part, on CREB activation. It was reported that SLAM signaling would induce the activation of the protein kinase Erk. To analyze the signaling pathways induced by SLAM that contribute to CREB activation and IFN-γ secretion in TB, we studied Erk phosphorylation after SLAM activation. The addition of PD90059 (an Erk inhibitor) to Mtb stimulated cells inhibited the percentage of IFN-γ+pCREB+ T cells, indicating that Erk could be involved on CREB activation. Moreover, the addition of PD90059 to Mtb±α-SLAM stimulated cells significantly decreased IFN-γ production (% inhibition: 71,6 ± 7,4). Finally, α-SLAM induced Erk activation in Mtb stimulated cells. These results demonstrate that IFN-γ production induced by SLAM signaling on Mtb stimulated cells is, at least in part, mediated by Erk and CREB phosphorylation. These data contribute new information about the molecular basis operating during SLAM activation that leads to IFN-γ production in human TB." @default.
- W4313344595 created "2023-01-06" @default.
- W4313344595 creator A5010560078 @default.
- W4313344595 creator A5023942545 @default.
- W4313344595 creator A5053536552 @default.
- W4313344595 creator A5065914155 @default.
- W4313344595 creator A5077176756 @default.
- W4313344595 creator A5085129079 @default.
- W4313344595 creator A5090937046 @default.
- W4313344595 creator A5091720875 @default.
- W4313344595 date "2010-04-01" @default.
- W4313344595 modified "2023-09-30" @default.
- W4313344595 title "SLAM activation induces ERK and CREB phosphorylation that leads to IFN-γ production during active tuberculosis (TB) (45.27)" @default.
- W4313344595 doi "https://doi.org/10.4049/jimmunol.184.supp.45.27" @default.
- W4313344595 hasPublicationYear "2010" @default.
- W4313344595 type Work @default.
- W4313344595 citedByCount "0" @default.
- W4313344595 crossrefType "journal-article" @default.
- W4313344595 hasAuthorship W4313344595A5010560078 @default.
- W4313344595 hasAuthorship W4313344595A5023942545 @default.
- W4313344595 hasAuthorship W4313344595A5053536552 @default.
- W4313344595 hasAuthorship W4313344595A5065914155 @default.
- W4313344595 hasAuthorship W4313344595A5077176756 @default.
- W4313344595 hasAuthorship W4313344595A5085129079 @default.
- W4313344595 hasAuthorship W4313344595A5090937046 @default.
- W4313344595 hasAuthorship W4313344595A5091720875 @default.
- W4313344595 hasConcept C104317684 @default.
- W4313344595 hasConcept C11960822 @default.
- W4313344595 hasConcept C134018914 @default.
- W4313344595 hasConcept C153911025 @default.
- W4313344595 hasConcept C1629964 @default.
- W4313344595 hasConcept C184235292 @default.
- W4313344595 hasConcept C185592680 @default.
- W4313344595 hasConcept C24998067 @default.
- W4313344595 hasConcept C55493867 @default.
- W4313344595 hasConcept C57074206 @default.
- W4313344595 hasConcept C62478195 @default.
- W4313344595 hasConcept C86339819 @default.
- W4313344595 hasConcept C86803240 @default.
- W4313344595 hasConcept C95444343 @default.
- W4313344595 hasConceptScore W4313344595C104317684 @default.
- W4313344595 hasConceptScore W4313344595C11960822 @default.
- W4313344595 hasConceptScore W4313344595C134018914 @default.
- W4313344595 hasConceptScore W4313344595C153911025 @default.
- W4313344595 hasConceptScore W4313344595C1629964 @default.
- W4313344595 hasConceptScore W4313344595C184235292 @default.
- W4313344595 hasConceptScore W4313344595C185592680 @default.
- W4313344595 hasConceptScore W4313344595C24998067 @default.
- W4313344595 hasConceptScore W4313344595C55493867 @default.
- W4313344595 hasConceptScore W4313344595C57074206 @default.
- W4313344595 hasConceptScore W4313344595C62478195 @default.
- W4313344595 hasConceptScore W4313344595C86339819 @default.
- W4313344595 hasConceptScore W4313344595C86803240 @default.
- W4313344595 hasConceptScore W4313344595C95444343 @default.
- W4313344595 hasIssue "1_Supplement" @default.
- W4313344595 hasLocation W43133445951 @default.
- W4313344595 hasOpenAccess W4313344595 @default.
- W4313344595 hasPrimaryLocation W43133445951 @default.
- W4313344595 hasRelatedWork W2000465491 @default.
- W4313344595 hasRelatedWork W2002575458 @default.
- W4313344595 hasRelatedWork W2015725807 @default.
- W4313344595 hasRelatedWork W2025548430 @default.
- W4313344595 hasRelatedWork W2091587849 @default.
- W4313344595 hasRelatedWork W2092282167 @default.
- W4313344595 hasRelatedWork W2156234897 @default.
- W4313344595 hasRelatedWork W2384817912 @default.
- W4313344595 hasRelatedWork W3035328115 @default.
- W4313344595 hasRelatedWork W4313354903 @default.
- W4313344595 hasVolume "184" @default.
- W4313344595 isParatext "false" @default.
- W4313344595 isRetracted "false" @default.
- W4313344595 workType "article" @default.