Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313344799> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W4313344799 endingPage "46.8" @default.
- W4313344799 startingPage "46.8" @default.
- W4313344799 abstract "Abstract ST6Gal I is a glycosyltransferase highly expressed by lymphocytes and cancer cells that catalyzes the addition of α2,6 sialic acid to galactose (Siaα2-6Gal) on N-linked glycoproteins. We discovered that ST6Gal I shows dramatic changes in gene expression during memory CD8 T cell differentiation that corresponds with lectin binding, but the significance of this regulated carbohydrate modification remained a mystery. To identify the significance of these regulated glyco-phenotypic changes, we infected ST6Gal I-/- mice and found that viral-specific cell expansion was impaired. Moreover, defective viral-specific CD8 T cell expansion was due to early intrinsic defects in proliferation of terminal effector cells, whereas memory precursor development was enhanced. We provide direct evidence that loss of ST6Gal I expression by CD8 T cells resulted in delayed surface expression of IL-2Rα in vivo due to impaired IL-2/IL-2R signaling. These results suggest that CD8 T cells regulate ST6Gal I expression to promote proliferation induced by cytokine-dependent signaling." @default.
- W4313344799 created "2023-01-06" @default.
- W4313344799 creator A5014929190 @default.
- W4313344799 creator A5018437430 @default.
- W4313344799 creator A5029930734 @default.
- W4313344799 creator A5034063212 @default.
- W4313344799 creator A5034088054 @default.
- W4313344799 creator A5054930067 @default.
- W4313344799 date "2011-04-01" @default.
- W4313344799 modified "2023-09-26" @default.
- W4313344799 title "ST6Gal I promotes rapid IL-2Rα expression and early proliferation of terminal effector CD8 T cells (46.8)" @default.
- W4313344799 doi "https://doi.org/10.4049/jimmunol.186.supp.46.8" @default.
- W4313344799 hasPublicationYear "2011" @default.
- W4313344799 type Work @default.
- W4313344799 citedByCount "0" @default.
- W4313344799 crossrefType "journal-article" @default.
- W4313344799 hasAuthorship W4313344799A5014929190 @default.
- W4313344799 hasAuthorship W4313344799A5018437430 @default.
- W4313344799 hasAuthorship W4313344799A5029930734 @default.
- W4313344799 hasAuthorship W4313344799A5034063212 @default.
- W4313344799 hasAuthorship W4313344799A5034088054 @default.
- W4313344799 hasAuthorship W4313344799A5054930067 @default.
- W4313344799 hasConcept C147483822 @default.
- W4313344799 hasConcept C153911025 @default.
- W4313344799 hasConcept C154317977 @default.
- W4313344799 hasConcept C167672396 @default.
- W4313344799 hasConcept C176324957 @default.
- W4313344799 hasConcept C202751555 @default.
- W4313344799 hasConcept C203014093 @default.
- W4313344799 hasConcept C2776090121 @default.
- W4313344799 hasConcept C51785407 @default.
- W4313344799 hasConcept C55493867 @default.
- W4313344799 hasConcept C62112901 @default.
- W4313344799 hasConcept C79484868 @default.
- W4313344799 hasConcept C86803240 @default.
- W4313344799 hasConcept C8891405 @default.
- W4313344799 hasConcept C95444343 @default.
- W4313344799 hasConceptScore W4313344799C147483822 @default.
- W4313344799 hasConceptScore W4313344799C153911025 @default.
- W4313344799 hasConceptScore W4313344799C154317977 @default.
- W4313344799 hasConceptScore W4313344799C167672396 @default.
- W4313344799 hasConceptScore W4313344799C176324957 @default.
- W4313344799 hasConceptScore W4313344799C202751555 @default.
- W4313344799 hasConceptScore W4313344799C203014093 @default.
- W4313344799 hasConceptScore W4313344799C2776090121 @default.
- W4313344799 hasConceptScore W4313344799C51785407 @default.
- W4313344799 hasConceptScore W4313344799C55493867 @default.
- W4313344799 hasConceptScore W4313344799C62112901 @default.
- W4313344799 hasConceptScore W4313344799C79484868 @default.
- W4313344799 hasConceptScore W4313344799C86803240 @default.
- W4313344799 hasConceptScore W4313344799C8891405 @default.
- W4313344799 hasConceptScore W4313344799C95444343 @default.
- W4313344799 hasIssue "1_Supplement" @default.
- W4313344799 hasLocation W43133447991 @default.
- W4313344799 hasOpenAccess W4313344799 @default.
- W4313344799 hasPrimaryLocation W43133447991 @default.
- W4313344799 hasRelatedWork W1491309847 @default.
- W4313344799 hasRelatedWork W1540340473 @default.
- W4313344799 hasRelatedWork W1553176079 @default.
- W4313344799 hasRelatedWork W2063492259 @default.
- W4313344799 hasRelatedWork W2093525495 @default.
- W4313344799 hasRelatedWork W2159389701 @default.
- W4313344799 hasRelatedWork W2952174619 @default.
- W4313344799 hasRelatedWork W3032085795 @default.
- W4313344799 hasRelatedWork W4313351690 @default.
- W4313344799 hasRelatedWork W4317608975 @default.
- W4313344799 hasVolume "186" @default.
- W4313344799 isParatext "false" @default.
- W4313344799 isRetracted "false" @default.
- W4313344799 workType "article" @default.