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- W4313344816 abstract "Abstract In response to pathogens, activated MØ frequently express COX-2, which mediates increased release of prostaglandin E2 (PGE2), regulating host defense and inflammatory responses. We previously demonstrated, however, that i.p. administration of HK- Mycobacterium bovis BCG or M. tuberculosis resulted within 24h in increased COX-2 formation, which was subcellularly dissociated from the nuclear envelope (NE), enzymatically inactive and mediated no PGE2 release in peritoneal MØ. In contrast, when normal peritoneal MØ isolated from mice or RAW264.7 MØ were activated for 24h in vitro by BCG, they expressed increased COX-2, which was subcellularly localized in the NE and mediated increased release of PGE2. To assess whether production of inactive COX-2 is associated with ER stress-dependent signaling, we measured selected ER stress protein levels in peritoneal MØ from C57Bl/6 mice and RAW264.7 MØ that were treated with BCG in vitro or in vivo. Literature indicates that in vivo administration of endotoxin has been shown to up-regulate ER stress responses. We found that ER stress proteins growth arrest and DNA-damage-inducible gene 153, glucose regulated protein 78, and the phosphorylation of eukaryotic initiation factor two were up-regulated in RAW264.7 MØ when stimulated with endotoxin, tunicamycin or thapsigargin. However, no detectable changes in ER stress proteins were found in BCG-treated RAW264.7 MØ, in vitro BCG-treated peritoneal MØ or in vivo BCG-treated peritoneal MØ. Our results indicate that mycobacterial activation of MØ COX-2 expression in vivo or in vitro does not involve ER stress/unfolded protein responses. (Supported by NIH HL71711, DOD DAMD 17-03-1-0004, BCCRP 06BS-04-9615)" @default.
- W4313344816 created "2023-01-06" @default.
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- W4313344816 date "2009-04-01" @default.
- W4313344816 modified "2023-10-18" @default.
- W4313344816 title "Mycobacteria induce the inactive form of cyclooxygenase-2 (COX-2) without inducing endoplasmic reticulum (ER) stress responses in local macrophages (Mνll]) (135.29)" @default.
- W4313344816 doi "https://doi.org/10.4049/jimmunol.182.supp.135.29" @default.
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