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• W4313345046 abstract "To migrate efficiently, neutrophils must polarize their cytoskeletal regulators along a single axis of motion. This polarization process is thought to be mediated through local positive feedback that amplifies leading edge signals and global negative feedback that enables sites of positive feedback to compete for dominance. Though this two-component model efficiently establishes cell polarity, it has potential limitations, including a tendency to “lock” onto a particular direction, limiting the ability of cells to reorient. We use spatially-defined optogenetic control of a leading edge organizer (PI3K) to probe how cells balance “decisiveness” needed to polarize in a single direction with the flexibility needed to respond to new cues. Underlying this balancing act is a local Rac inhibitor that destabilizes the leading edge to promote exploration. We show that this local inhibitor enables cells to process input signal dynamics, linking front stability and orientation to local temporal increases in input signals." @default.
• W4313345046 created "2023-01-06" @default.
• W4313345046 creator A5039788638 @default.
• W4313345046 creator A5076309635 @default.
• W4313345046 date "2022-12-31" @default.
• W4313345046 modified "2023-09-26" @default.
• W4313345046 title "Rac negative feedback links local PIP₃rate-of-change to dynamic control of neutrophil guidance" @default.
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• W4313345046 doi "https://doi.org/10.1101/2022.12.30.521706" @default.
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