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• W4313346064 endingPage "116" @default.
• W4313346064 startingPage "104" @default.
• W4313346064 abstract "The relationship between brain microstructure and aging has been the subject of intense study, with diffusion MRI perhaps the most effective modality for elucidating these associations. Here, we used the mean apparent propagator (MAP)-MRI framework, which is suitable to characterize complex microstructure, to investigate age-related cerebral differences in a cohort of cognitively unimpaired participants and compared the results to those derived using diffusion tensor imaging. We studied MAP-MRI metrics, among them the non-Gaussianity (NG) and propagator anisotropy (PA), and established an opposing pattern in white matter of higher NG alongside lower PA among older adults, likely indicative of axonal degradation. In gray matter, however, these two indices were consistent with one another, and exhibited regional pattern heterogeneity compared to other microstructural parameters, which could indicate fewer neuronal projections across cortical layers along with an increased glial concentration. In addition, we report regional variations in the magnitude of age-related microstructural differences consistent with the posterior-anterior shift in aging paradigm. These results encourage further investigations in cognitive impairments and neurodegeneration." @default.
• W4313346064 created "2023-01-06" @default.
• W4313346064 creator A5018530204 @default.
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• W4313346064 date "2023-04-01" @default.
• W4313346064 modified "2023-09-30" @default.
• W4313346064 title "Adult lifespan maturation and degeneration patterns in gray and white matter: A mean apparent propagator (MAP) MRI study" @default.
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• W4313346064 doi "https://doi.org/10.1016/j.neurobiolaging.2022.12.016" @default.
• W4313346064 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36641369" @default.
• W4313346064 hasPublicationYear "2023" @default.
• W4313346064 type Work @default.

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