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- W4313346093 abstract "For plants, distinguishing between mutualistic and pathogenic microbes is a matter of survival. All microbes contain microbe-associated molecular patterns (MAMPs) that are perceived by plant pattern recognition receptors (PRRs). Lysin motif receptor-like kinases (LysM-RLKs) are PRRs attuned for binding and triggering a response to specific MAMPs, including chitin oligomers (COs) in fungi, lipo-chitooligosaccharides (LCOs), which are produced by mycorrhizal fungi and nitrogen-fixing rhizobial bacteria, and peptidoglycan in bacteria. The identification and characterization of LysM-RLKs in candidate bioenergy crops including Populus are limited compared to other model plant species, thus inhibiting our ability to both understand and engineer microbe-mediated gains in plant productivity. As such, we performed a sequence analysis of LysM-RLKs in the Populus genome and predicted their function based on phylogenetic analysis with known LysM-RLKs. Then, using predictive models, molecular dynamics simulations, and comparative structural analysis with previously characterized CO and LCO plant receptors, we identified probable ligand-binding sites in Populus LysM-RLKs. Using several machine learning models, we predicted remarkably consistent binding affinity rankings of Populus proteins to CO. In addition, we used a modified Random Walk with Restart network-topology based approach to identify a subset of Populus LysM-RLKs that are functionally related and propose a corresponding signal transduction cascade. Our findings provide the first look into the role of LysM-RLKs in Populus-microbe interactions and establish a crucial jumping-off point for future research efforts to understand specificity and redundancy in microbial perception mechanisms." @default.
- W4313346093 created "2023-01-06" @default.
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- W4313346093 date "2023-01-01" @default.
- W4313346093 modified "2023-09-30" @default.
- W4313346093 title "Exploring the role of plant lysin motif receptor-like kinases in regulating plant-microbe interactions in the bioenergy crop Populus" @default.
- W4313346093 cites W1031578623 @default.
- W4313346093 cites W1582209539 @default.
- W4313346093 cites W1782270454 @default.
- W4313346093 cites W1969017960 @default.
- W4313346093 cites W1969189143 @default.
- W4313346093 cites W1974624556 @default.
- W4313346093 cites W1976426459 @default.
- W4313346093 cites W1978399367 @default.
- W4313346093 cites W1979909854 @default.
- W4313346093 cites W1988790447 @default.
- W4313346093 cites W1993046136 @default.
- W4313346093 cites W1994204271 @default.
- W4313346093 cites W2000533911 @default.
- W4313346093 cites W2007524405 @default.
- W4313346093 cites W2011081708 @default.
- W4313346093 cites W2011301426 @default.
- W4313346093 cites W2011955979 @default.
- W4313346093 cites W2018824767 @default.
- W4313346093 cites W2022037801 @default.
- W4313346093 cites W2029542221 @default.
- W4313346093 cites W2029667189 @default.
- W4313346093 cites W2031565991 @default.
- W4313346093 cites W2036539500 @default.
- W4313346093 cites W2036598163 @default.
- W4313346093 cites W2047542752 @default.
- W4313346093 cites W2049475242 @default.
- W4313346093 cites W2050187930 @default.
- W4313346093 cites W2050607290 @default.
- W4313346093 cites W2051026120 @default.
- W4313346093 cites W2075768471 @default.
- W4313346093 cites W2077404754 @default.
- W4313346093 cites W2078369877 @default.
- W4313346093 cites W2083522928 @default.
- W4313346093 cites W2090114393 @default.
- W4313346093 cites W2091759802 @default.
- W4313346093 cites W2092285329 @default.
- W4313346093 cites W2109154308 @default.
- W4313346093 cites W2113122247 @default.
- W4313346093 cites W2114162221 @default.
- W4313346093 cites W2115568096 @default.
- W4313346093 cites W2115705289 @default.
- W4313346093 cites W2116351978 @default.
- W4313346093 cites W2117029402 @default.
- W4313346093 cites W2117748371 @default.
- W4313346093 cites W2118747538 @default.
- W4313346093 cites W2119002152 @default.
- W4313346093 cites W2120840313 @default.
- W4313346093 cites W2125346198 @default.
- W4313346093 cites W2125627131 @default.
- W4313346093 cites W2125725340 @default.
- W4313346093 cites W2127380820 @default.
- W4313346093 cites W2129897639 @default.
- W4313346093 cites W2132926880 @default.
- W4313346093 cites W2133963159 @default.
- W4313346093 cites W2134314409 @default.
- W4313346093 cites W2138210064 @default.
- W4313346093 cites W2140673705 @default.
- W4313346093 cites W2141292707 @default.
- W4313346093 cites W2141723230 @default.
- W4313346093 cites W2141976900 @default.
- W4313346093 cites W2142882714 @default.
- W4313346093 cites W2142996073 @default.
- W4313346093 cites W2146052495 @default.
- W4313346093 cites W2147863419 @default.
- W4313346093 cites W2148387676 @default.
- W4313346093 cites W2152207030 @default.
- W4313346093 cites W2153439773 @default.
- W4313346093 cites W2157855183 @default.
- W4313346093 cites W2159675211 @default.
- W4313346093 cites W2160737163 @default.
- W4313346093 cites W2166397221 @default.
- W4313346093 cites W2166795661 @default.
- W4313346093 cites W2168452914 @default.
- W4313346093 cites W2173962429 @default.
- W4313346093 cites W2211345037 @default.
- W4313346093 cites W2263772370 @default.
- W4313346093 cites W2299056448 @default.
- W4313346093 cites W2343705214 @default.