FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313347702> ?p ?o ?g. }

• W4313347702 endingPage "3368" @default.
• W4313347702 startingPage "3363" @default.
• W4313347702 abstract "Abstract The proopiomelanocortin (POMC)-derived neuropeptide α-melanocyte stimulating hormone (α-MSH) is known to modulate some aspects of inflammation through direct effects on T cells, B cells, and monocytes. To determine whether α-MSH might similarly influence mast cell responsiveness, mast cells were examined to see if they expressed the receptor for α-MSH, melanocortin-1 (MC-1), and whether α-MSH altered mast cell function. We thus first identified MC-1 on bone marrow cultured murine mast cells (BMCMC) and a murine mast cell line (MCP-5) employing flow cytometry and through detection of specific binding. Subsequent treatment of mast cells with α-MSH increased the cAMP concentration in a characteristic biphasic pattern, demonstrating that α-MSH could affect intracellular processes. We next examined the effect of α-MSH on mediator release and cytokine expression. IgE/DNP-human serum albumin-stimulated histamine release from mast cells was inhibited by ∼60% in the presence of α-MSH. Although activation of BMCMC induced the expression of mRNAs for the inflammatory cytokines IL-1β, IL-4, IL-6, TNF-α, and the chemokine lymphotactin, mRNAs for IL-1β, TNF-α, and lymphotactin were down-modulated in the presence of α-MSH. Finally, IL-3-dependent proliferative activity of BMCMC was slightly but significantly augmented by α-MSH. Taken together, these observations suggest that α-MSH may exert an inhibitory effect on the mast cell-dependent component of a specific inflammatory response." @default.
• W4313347702 created "2023-01-06" @default.
• W4313347702 creator A5011039354 @default.
• W4313347702 creator A5037072498 @default.
• W4313347702 creator A5044052133 @default.
• W4313347702 creator A5055091287 @default.
• W4313347702 date "1999-09-15" @default.
• W4313347702 modified "2023-10-11" @default.
• W4313347702 title "Receptor-Mediated Modulation of Murine Mast Cell Function by α-Melanocyte Stimulating Hormone" @default.
• W4313347702 cites W1493400757 @default.
• W4313347702 cites W1496339398 @default.
• W4313347702 cites W1502422472 @default.
• W4313347702 cites W1511593691 @default.
• W4313347702 cites W1524123582 @default.
• W4313347702 cites W1546967572 @default.
• W4313347702 cites W1566308385 @default.
• W4313347702 cites W1581243959 @default.
• W4313347702 cites W1583971934 @default.
• W4313347702 cites W1593022712 @default.
• W4313347702 cites W1598422803 @default.
• W4313347702 cites W1709882622 @default.
• W4313347702 cites W1889056855 @default.
• W4313347702 cites W1925917964 @default.
• W4313347702 cites W1950481374 @default.
• W4313347702 cites W1965380787 @default.
• W4313347702 cites W1969066564 @default.
• W4313347702 cites W1970951686 @default.
• W4313347702 cites W1973223056 @default.
• W4313347702 cites W1973449234 @default.
• W4313347702 cites W1974291199 @default.
• W4313347702 cites W1979420492 @default.
• W4313347702 cites W1982633594 @default.
• W4313347702 cites W1984762923 @default.
• W4313347702 cites W1989033543 @default.
• W4313347702 cites W1992376539 @default.
• W4313347702 cites W2003416023 @default.
• W4313347702 cites W2015690288 @default.
• W4313347702 cites W2016433042 @default.
• W4313347702 cites W2024828070 @default.
• W4313347702 cites W2026496827 @default.
• W4313347702 cites W2027158671 @default.
• W4313347702 cites W2031951021 @default.
• W4313347702 cites W2054868496 @default.
• W4313347702 cites W2055289549 @default.
• W4313347702 cites W2074185798 @default.
• W4313347702 cites W2078549474 @default.
• W4313347702 cites W2078880170 @default.
• W4313347702 cites W2081839011 @default.
• W4313347702 cites W2088017464 @default.
• W4313347702 cites W2115106619 @default.
• W4313347702 cites W2116308270 @default.
• W4313347702 cites W2121252248 @default.
• W4313347702 cites W2130476194 @default.
• W4313347702 cites W2156619469 @default.
• W4313347702 cites W2166625431 @default.
• W4313347702 cites W2168604311 @default.
• W4313347702 cites W4255354355 @default.
• W4313347702 cites W4313333804 @default.
• W4313347702 doi "https://doi.org/10.4049/jimmunol.163.6.3363" @default.
• W4313347702 hasPublicationYear "1999" @default.
• W4313347702 type Work @default.
• W4313347702 citedByCount "32" @default.
• W4313347702 countsByYear W43133477022012 @default.
• W4313347702 countsByYear W43133477022013 @default.
• W4313347702 countsByYear W43133477022014 @default.
• W4313347702 countsByYear W43133477022015 @default.
• W4313347702 countsByYear W43133477022018 @default.
• W4313347702 countsByYear W43133477022021 @default.
• W4313347702 countsByYear W43133477022023 @default.
• W4313347702 crossrefType "journal-article" @default.
• W4313347702 hasAuthorship W4313347702A5011039354 @default.
• W4313347702 hasAuthorship W4313347702A5037072498 @default.
• W4313347702 hasAuthorship W4313347702A5044052133 @default.
• W4313347702 hasAuthorship W4313347702A5055091287 @default.
• W4313347702 hasBestOaLocation W43133477021 @default.
• W4313347702 hasConcept C1122143 @default.
• W4313347702 hasConcept C126322002 @default.
• W4313347702 hasConcept C13373296 @default.
• W4313347702 hasConcept C134018914 @default.
• W4313347702 hasConcept C170493617 @default.
• W4313347702 hasConcept C181901479 @default.
• W4313347702 hasConcept C185592680 @default.
• W4313347702 hasConcept C203014093 @default.
• W4313347702 hasConcept C2776914184 @default.
• W4313347702 hasConcept C2778690821 @default.
• W4313347702 hasConcept C2779726688 @default.
• W4313347702 hasConcept C2780989459 @default.
• W4313347702 hasConcept C2781309135 @default.
• W4313347702 hasConcept C71315377 @default.
• W4313347702 hasConcept C71924100 @default.
• W4313347702 hasConcept C74172505 @default.
• W4313347702 hasConcept C86803240 @default.
• W4313347702 hasConcept C95444343 @default.
• W4313347702 hasConceptScore W4313347702C1122143 @default.
• W4313347702 hasConceptScore W4313347702C126322002 @default.
• W4313347702 hasConceptScore W4313347702C13373296 @default.
• W4313347702 hasConceptScore W4313347702C134018914 @default.
• W4313347702 hasConceptScore W4313347702C170493617 @default.

• next