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• W4313347710 startingPage "5449" @default.
• W4313347710 abstract "Abstract The importance of IFN-γ in regulating the host CD8+ T cell response during microbial infection has not been delineated. Mice deficient for the p40 chain of the IL-12 heterodimer have impaired IFN-γ production and are susceptible to infection with the intracellular parasite Toxoplasma gondii. The administration of exogenous IFN-γ to parasite-infected p40−/− mice increases survival and up-regulates the depressed CD8+ T cell response following infection. CD8+ T cells isolated from cytokine-treated p40−/− mice exhibit an increase in both precursor CTL frequency and IFN-γ production compared with untreated controls. The enhancement of the CD8+ T cell response is independent of CD4+ T cell help. These CD8+ T cells induce protective immunity against a lethal challenge when adoptively transferred into naive p40−/− and IFN-γ−/− mice. These observations indicate that IFN-γ can regulate the CD8+ T cell response during T. gondii infection." @default.
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• W4313347710 date "1999-05-01" @default.
• W4313347710 modified "2023-10-15" @default.
• W4313347710 title "Augmentation of the CD8+ T Cell Response by IFN-γ in IL-12-Deficient Mice During<i>Toxoplasma gondii</i>Infection" @default.
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• W4313347710 doi "https://doi.org/10.4049/jimmunol.162.9.5449" @default.
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