Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313347802> ?p ?o ?g. }
- W4313347802 endingPage "3483" @default.
- W4313347802 startingPage "3474" @default.
- W4313347802 abstract "Abstract NF-κB plays a critical role in the transcriptional regulation of proinflammatory gene expression in various cells. Cytokine-mediated activation of NF-κB requires activation of various kinases, which ultimately leads to the phosphorylation and degradation of IκB, the NF-κB cytoplasmic inhibitor. The food derivative curcumin has been shown to inhibit NF-κB activity in some cell types. In this report we investigate the mechanism of action of curcumin on cytokine-induced proinflammatory gene expression using intestinal epithelial cells (IEC). Curcumin inhibited IL-1β-mediated ICAM-1 and IL-8 gene expression in IEC-6, HT-29, and Caco-2 cells. Cytokine-induced NF-κB DNA binding activity, RelA nuclear translocation, IκBα degradation, IκB serine 32 phosphorylation, and IκB kinase (IKK) activity were blocked by curcumin treatment. Wound-induced p38 phosphorylation was not inhibited by curcumin treatment. In addition, mitogen-activated protein kinase/ERK kinase kinase-1-induced IL-8 gene expression and 12-O-tetraphorbol 12-myristate 13-acetate-responsive element-driven luciferase expression were inhibited by curcumin. However, IκBα degradation induced by ectopically expressed NF-κB-inducing kinase or IKK was not inhibited by curcumin treatment. Therefore, curcumin blocks a signal upstream of NF-κB-inducing kinase and IKK. We conclude that curcumin potently inhibits cytokine-mediated NF-κB activation by blocking a signal leading to IKK activity." @default.
- W4313347802 created "2023-01-06" @default.
- W4313347802 creator A5011876248 @default.
- W4313347802 creator A5015535660 @default.
- W4313347802 creator A5021079397 @default.
- W4313347802 creator A5045420349 @default.
- W4313347802 creator A5049586381 @default.
- W4313347802 creator A5053799271 @default.
- W4313347802 creator A5070623834 @default.
- W4313347802 date "1999-09-15" @default.
- W4313347802 modified "2023-10-14" @default.
- W4313347802 title "Curcumin Blocks Cytokine-Mediated NF-κB Activation and Proinflammatory Gene Expression by Inhibiting Inhibitory Factor I-κB Kinase Activity" @default.
- W4313347802 cites W147937549 @default.
- W4313347802 cites W1558367558 @default.
- W4313347802 cites W1599671902 @default.
- W4313347802 cites W1786911182 @default.
- W4313347802 cites W1919832973 @default.
- W4313347802 cites W1965144265 @default.
- W4313347802 cites W1971425598 @default.
- W4313347802 cites W1972414794 @default.
- W4313347802 cites W1975055683 @default.
- W4313347802 cites W1979595147 @default.
- W4313347802 cites W1980768491 @default.
- W4313347802 cites W1986242902 @default.
- W4313347802 cites W1995038174 @default.
- W4313347802 cites W1997509253 @default.
- W4313347802 cites W2006115758 @default.
- W4313347802 cites W2007986629 @default.
- W4313347802 cites W2011781801 @default.
- W4313347802 cites W2011843272 @default.
- W4313347802 cites W2012016116 @default.
- W4313347802 cites W2020300507 @default.
- W4313347802 cites W2027799502 @default.
- W4313347802 cites W2031112206 @default.
- W4313347802 cites W2032514624 @default.
- W4313347802 cites W2035308484 @default.
- W4313347802 cites W2036770241 @default.
- W4313347802 cites W2048639599 @default.
- W4313347802 cites W2052426854 @default.
- W4313347802 cites W2061726942 @default.
- W4313347802 cites W2062205148 @default.
- W4313347802 cites W2064558057 @default.
- W4313347802 cites W2067680656 @default.
- W4313347802 cites W2068319331 @default.
- W4313347802 cites W2068913584 @default.
- W4313347802 cites W2070853191 @default.
- W4313347802 cites W2077575210 @default.
- W4313347802 cites W2082157761 @default.
- W4313347802 cites W2085837280 @default.
- W4313347802 cites W2089394364 @default.
- W4313347802 cites W2089938437 @default.
- W4313347802 cites W2092032160 @default.
- W4313347802 cites W2124202816 @default.
- W4313347802 cites W2127460630 @default.
- W4313347802 cites W2151892297 @default.
- W4313347802 cites W2152530163 @default.
- W4313347802 cites W2158708535 @default.
- W4313347802 cites W2159979956 @default.
- W4313347802 cites W2165342216 @default.
- W4313347802 cites W2166781237 @default.
- W4313347802 cites W2171914962 @default.
- W4313347802 cites W2195375524 @default.
- W4313347802 cites W2331176038 @default.
- W4313347802 cites W4230299891 @default.
- W4313347802 cites W4313377080 @default.
- W4313347802 cites W64336563 @default.
- W4313347802 doi "https://doi.org/10.4049/jimmunol.163.6.3474" @default.
- W4313347802 hasPublicationYear "1999" @default.
- W4313347802 type Work @default.
- W4313347802 citedByCount "372" @default.
- W4313347802 countsByYear W43133478022012 @default.
- W4313347802 countsByYear W43133478022013 @default.
- W4313347802 countsByYear W43133478022014 @default.
- W4313347802 countsByYear W43133478022015 @default.
- W4313347802 countsByYear W43133478022016 @default.
- W4313347802 countsByYear W43133478022017 @default.
- W4313347802 countsByYear W43133478022018 @default.
- W4313347802 countsByYear W43133478022019 @default.
- W4313347802 countsByYear W43133478022020 @default.
- W4313347802 countsByYear W43133478022021 @default.
- W4313347802 countsByYear W43133478022022 @default.
- W4313347802 countsByYear W43133478022023 @default.
- W4313347802 crossrefType "journal-article" @default.
- W4313347802 hasAuthorship W4313347802A5011876248 @default.
- W4313347802 hasAuthorship W4313347802A5015535660 @default.
- W4313347802 hasAuthorship W4313347802A5021079397 @default.
- W4313347802 hasAuthorship W4313347802A5045420349 @default.
- W4313347802 hasAuthorship W4313347802A5049586381 @default.
- W4313347802 hasAuthorship W4313347802A5053799271 @default.
- W4313347802 hasAuthorship W4313347802A5070623834 @default.
- W4313347802 hasBestOaLocation W43133478021 @default.
- W4313347802 hasConcept C100175707 @default.
- W4313347802 hasConcept C11960822 @default.
- W4313347802 hasConcept C153911025 @default.
- W4313347802 hasConcept C164027704 @default.
- W4313347802 hasConcept C184235292 @default.
- W4313347802 hasConcept C185592680 @default.
- W4313347802 hasConcept C203014093 @default.