FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313347811> ?p ?o ?g. }

• W4313347811 endingPage "969" @default.
• W4313347811 startingPage "963" @default.
• W4313347811 abstract "Abstract The pathogenesis of septicemia can be triggered by LPS, a potent stimulus for PG synthesis. The enzyme cyclooxygenase (COX) is a rate-limiting step in PG production. COX exists as two isoforms: COX-1, which is constitutively expressed in most cell types, and COX-2, which is inducible by LPS and cytokines in a variety of cells. In this study we determined the role of the proinflammatory cytokines IL-1β and TNF-α released by LPS-stimulated U937 human macrophages in the regulation of COX-2. Macrophages exposed to LPS showed a rapid and sustained expression of COX-2 mRNA and protein for up to 48 h, whereas PGE2 production was notably enhanced only after 12 h. LPS increased COX-2 gene transcription and activation of the transcription factor NF-κB in a transient manner. LPS-treated macrophages produced high levels of TNF-α and moderate amounts of IL-1β protein. However, neutralizing Abs against these cytokines had no effect on COX-2 mRNA and protein expression, nor did they affect the stability of COX-2 mRNA. Interestingly, in the presence of LPS or exogenous IL-1β, COX-2 transcripts were stabilized, and actinomycin D inhibited their degradation. Only when LPS or IL-1β was removed did COX-2 mRNA decay with a t1/2 of ≥5 h. In contrast, dexamethasone promoted a faster decay of the LPS-induced COX-2 transcripts (t1/2 = 2.5 h). These results clearly demonstrate that LPS can regulate COX-2 at both transcriptional and posttranscriptional levels independently from endogenous IL-1β and TNF-α in human macrophages." @default.
• W4313347811 created "2023-01-06" @default.
• W4313347811 creator A5013575325 @default.
• W4313347811 creator A5065044412 @default.
• W4313347811 creator A5078279956 @default.
• W4313347811 date "1999-07-15" @default.
• W4313347811 modified "2023-10-16" @default.
• W4313347811 title "Lipopolysaccharide Modulates Cyclooxygenase-2 Transcriptionally and Posttranscriptionally in Human Macrophages Independently from Endogenous IL-1β and TNF-α" @default.
• W4313347811 cites W1500692723 @default.
• W4313347811 cites W1514928695 @default.
• W4313347811 cites W1536031017 @default.
• W4313347811 cites W1545327957 @default.
• W4313347811 cites W1562546679 @default.
• W4313347811 cites W1660693249 @default.
• W4313347811 cites W1899889608 @default.
• W4313347811 cites W1901924975 @default.
• W4313347811 cites W1948940407 @default.
• W4313347811 cites W1950460235 @default.
• W4313347811 cites W1963550266 @default.
• W4313347811 cites W1974822812 @default.
• W4313347811 cites W1976326847 @default.
• W4313347811 cites W1988449214 @default.
• W4313347811 cites W1988894941 @default.
• W4313347811 cites W1989351016 @default.
• W4313347811 cites W1999208756 @default.
• W4313347811 cites W2002708977 @default.
• W4313347811 cites W2003719859 @default.
• W4313347811 cites W2012276221 @default.
• W4313347811 cites W2012642617 @default.
• W4313347811 cites W2029256011 @default.
• W4313347811 cites W2037328302 @default.
• W4313347811 cites W2044848545 @default.
• W4313347811 cites W2049908664 @default.
• W4313347811 cites W2061313641 @default.
• W4313347811 cites W2064124917 @default.
• W4313347811 cites W2065638310 @default.
• W4313347811 cites W2080532845 @default.
• W4313347811 cites W2082728629 @default.
• W4313347811 cites W2085680573 @default.
• W4313347811 cites W2089923844 @default.
• W4313347811 cites W2094055423 @default.
• W4313347811 cites W2096259566 @default.
• W4313347811 cites W2132579331 @default.
• W4313347811 cites W2136614974 @default.
• W4313347811 cites W2139510950 @default.
• W4313347811 cites W2142784507 @default.
• W4313347811 cites W2143879276 @default.
• W4313347811 cites W2245807703 @default.
• W4313347811 cites W2265083863 @default.
• W4313347811 cites W2281386564 @default.
• W4313347811 cites W2407462182 @default.
• W4313347811 cites W2419237723 @default.
• W4313347811 cites W4313347902 @default.
• W4313347811 cites W4321258480 @default.
• W4313347811 doi "https://doi.org/10.4049/jimmunol.163.2.963" @default.
• W4313347811 hasPublicationYear "1999" @default.
• W4313347811 type Work @default.
• W4313347811 citedByCount "65" @default.
• W4313347811 countsByYear W43133478112012 @default.
• W4313347811 countsByYear W43133478112014 @default.
• W4313347811 countsByYear W43133478112015 @default.
• W4313347811 countsByYear W43133478112018 @default.
• W4313347811 countsByYear W43133478112020 @default.
• W4313347811 countsByYear W43133478112021 @default.
• W4313347811 countsByYear W43133478112022 @default.
• W4313347811 countsByYear W43133478112023 @default.
• W4313347811 crossrefType "journal-article" @default.
• W4313347811 hasAuthorship W4313347811A5013575325 @default.
• W4313347811 hasAuthorship W4313347811A5065044412 @default.
• W4313347811 hasAuthorship W4313347811A5078279956 @default.
• W4313347811 hasBestOaLocation W43133478111 @default.
• W4313347811 hasConcept C104317684 @default.
• W4313347811 hasConcept C105580179 @default.
• W4313347811 hasConcept C138885662 @default.
• W4313347811 hasConcept C153911025 @default.
• W4313347811 hasConcept C164027704 @default.
• W4313347811 hasConcept C16613235 @default.
• W4313347811 hasConcept C17991360 @default.
• W4313347811 hasConcept C179926584 @default.
• W4313347811 hasConcept C181199279 @default.
• W4313347811 hasConcept C185592680 @default.
• W4313347811 hasConcept C203014093 @default.
• W4313347811 hasConcept C2776914184 @default.
• W4313347811 hasConcept C2778754761 @default.
• W4313347811 hasConcept C2779689624 @default.
• W4313347811 hasConcept C41895202 @default.
• W4313347811 hasConcept C53345823 @default.
• W4313347811 hasConcept C55493867 @default.
• W4313347811 hasConcept C86803240 @default.
• W4313347811 hasConcept C95444343 @default.
• W4313347811 hasConceptScore W4313347811C104317684 @default.
• W4313347811 hasConceptScore W4313347811C105580179 @default.
• W4313347811 hasConceptScore W4313347811C138885662 @default.
• W4313347811 hasConceptScore W4313347811C153911025 @default.
• W4313347811 hasConceptScore W4313347811C164027704 @default.
• W4313347811 hasConceptScore W4313347811C16613235 @default.
• W4313347811 hasConceptScore W4313347811C17991360 @default.
• W4313347811 hasConceptScore W4313347811C179926584 @default.

• next