Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313347838> ?p ?o ?g. }
- W4313347838 endingPage "4461" @default.
- W4313347838 startingPage "4453" @default.
- W4313347838 abstract "Abstract The NF-κB family of transcription factors are associated with the regulation of innate and adaptive immunity to infection. Infection of C57BL/6 mice with Toxoplasma gondii resulted in up-regulation of NF-κB activity that included the NF-κB family member RelB. To assess the role of RelB in the regulation of the immune response to this infection, we challenged RelB-deficient mice (RelB−/−) and wild-type (WT) littermate controls with T. gondii. Although WT controls were resistant to T. gondii, RelB−/− mice succumbed 10–15 days after infection. Examination of accessory cell functions associated with resistance to T. gondii revealed that RelB−/− macrophages stimulated with IFN-γ plus LPS or TNF-α produced IL-12 as well as reactive nitrogen intermediates and inhibited parasite replication similar to WT macrophages. Analysis of the systemic responses of RelB−/− and WT mice revealed that infected mice had similar serum levels of IL-12. However, RelB−/− mice challenged with T. gondii produced negligible levels of IFN-γ and had reduced NK cell activity compared with WT mice. Similarly, splenocytes from uninfected RelB−/− mice stimulated with polyclonal stimuli were deficient in their ability to produce IFN-γ. Together, our results demonstrate that RelB is essential for the development of innate NK and adaptive T cell responses that lead to the production of IFN-γ and resistance to T. gondii." @default.
- W4313347838 created "2023-01-06" @default.
- W4313347838 creator A5017519824 @default.
- W4313347838 creator A5023556785 @default.
- W4313347838 creator A5043178995 @default.
- W4313347838 creator A5049309702 @default.
- W4313347838 creator A5064693777 @default.
- W4313347838 date "1999-10-15" @default.
- W4313347838 modified "2023-10-16" @default.
- W4313347838 title "The NF-κB Family Member RelB Is Required for Innate and Adaptive Immunity to<i>Toxoplasma gondii</i>" @default.
- W4313347838 cites W140877157 @default.
- W4313347838 cites W1483162601 @default.
- W4313347838 cites W1492063880 @default.
- W4313347838 cites W1507553134 @default.
- W4313347838 cites W1536927421 @default.
- W4313347838 cites W1537440990 @default.
- W4313347838 cites W1545910465 @default.
- W4313347838 cites W1580262749 @default.
- W4313347838 cites W1583712812 @default.
- W4313347838 cites W1588586944 @default.
- W4313347838 cites W1592276905 @default.
- W4313347838 cites W1595516692 @default.
- W4313347838 cites W1657346095 @default.
- W4313347838 cites W1661140311 @default.
- W4313347838 cites W1817160237 @default.
- W4313347838 cites W1820099508 @default.
- W4313347838 cites W1925420621 @default.
- W4313347838 cites W1933250835 @default.
- W4313347838 cites W1964323924 @default.
- W4313347838 cites W1968219928 @default.
- W4313347838 cites W1969489226 @default.
- W4313347838 cites W1972771670 @default.
- W4313347838 cites W1974383709 @default.
- W4313347838 cites W1975602003 @default.
- W4313347838 cites W1981217700 @default.
- W4313347838 cites W1984408134 @default.
- W4313347838 cites W1988563171 @default.
- W4313347838 cites W1988820544 @default.
- W4313347838 cites W1989914829 @default.
- W4313347838 cites W1991464867 @default.
- W4313347838 cites W1993620754 @default.
- W4313347838 cites W1997512963 @default.
- W4313347838 cites W1998047654 @default.
- W4313347838 cites W2018718597 @default.
- W4313347838 cites W2033810895 @default.
- W4313347838 cites W2035680000 @default.
- W4313347838 cites W2046265685 @default.
- W4313347838 cites W2051576341 @default.
- W4313347838 cites W2057618822 @default.
- W4313347838 cites W2058854516 @default.
- W4313347838 cites W2059257512 @default.
- W4313347838 cites W2062811432 @default.
- W4313347838 cites W2066868766 @default.
- W4313347838 cites W2068683559 @default.
- W4313347838 cites W2087148913 @default.
- W4313347838 cites W2092192751 @default.
- W4313347838 cites W2104583512 @default.
- W4313347838 cites W2106877484 @default.
- W4313347838 cites W2108473659 @default.
- W4313347838 cites W2114917219 @default.
- W4313347838 cites W2115431456 @default.
- W4313347838 cites W2117079340 @default.
- W4313347838 cites W2147507133 @default.
- W4313347838 cites W2149673255 @default.
- W4313347838 cites W2152420574 @default.
- W4313347838 cites W2167951497 @default.
- W4313347838 cites W2171345725 @default.
- W4313347838 cites W2342508582 @default.
- W4313347838 cites W340354993 @default.
- W4313347838 cites W4313333851 @default.
- W4313347838 cites W4313333862 @default.
- W4313347838 doi "https://doi.org/10.4049/jimmunol.163.8.4453" @default.
- W4313347838 hasPublicationYear "1999" @default.
- W4313347838 type Work @default.
- W4313347838 citedByCount "89" @default.
- W4313347838 countsByYear W43133478382012 @default.
- W4313347838 countsByYear W43133478382013 @default.
- W4313347838 countsByYear W43133478382014 @default.
- W4313347838 countsByYear W43133478382015 @default.
- W4313347838 countsByYear W43133478382017 @default.
- W4313347838 countsByYear W43133478382018 @default.
- W4313347838 countsByYear W43133478382019 @default.
- W4313347838 countsByYear W43133478382021 @default.
- W4313347838 countsByYear W43133478382022 @default.
- W4313347838 countsByYear W43133478382023 @default.
- W4313347838 crossrefType "journal-article" @default.
- W4313347838 hasAuthorship W4313347838A5017519824 @default.
- W4313347838 hasAuthorship W4313347838A5023556785 @default.
- W4313347838 hasAuthorship W4313347838A5043178995 @default.
- W4313347838 hasAuthorship W4313347838A5049309702 @default.
- W4313347838 hasAuthorship W4313347838A5064693777 @default.
- W4313347838 hasBestOaLocation W43133478381 @default.
- W4313347838 hasConcept C104317684 @default.
- W4313347838 hasConcept C123298856 @default.
- W4313347838 hasConcept C136449434 @default.
- W4313347838 hasConcept C159654299 @default.
- W4313347838 hasConcept C193419808 @default.
- W4313347838 hasConcept C203014093 @default.