FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313347851> ?p ?o ?g. }

• W4313347851 endingPage "2508" @default.
• W4313347851 startingPage "2501" @default.
• W4313347851 abstract "Abstract In this study, an in vitro flow model and a blocking mAb to P-selectin glycoprotein ligand-1 (PSGL-1) were used to define the role of PSGL-1 in monocyte attachment and rolling on E- and P-selectin and in attachment and accumulation on 6-h TNF-α-activated HUVEC. KPL1, an adhesion-blocking mAb directed against the tyrosine sulfate motif of PSGL-1, abolished monocyte-adhesive interactions with P-selectin, but only partially blocked monocyte interaction with E-selectin. Further analysis showed that on E-selectin, KPL1 blocked only secondary (i.e., monocyte/monocyte) interactions, but did not block primary (i.e., monocyte/E-selectin) interactions, with secondary adhesion accounting for 90% of the total adhesive interactions on either E- or P-selectin. On cytokine-activated HUVEC, monocytes initially attached and formed linear strings of adherent cells, which involved both primary and secondary adhesion. PSGL-1 or L-selectin mAb reduced string formation, and the combination of PSGL-1 and L-selectin mAb prevented monocyte strings and inhibited 86% of accumulation. Monocyte attachment and rolling on purified adherent monocytes were also critically dependent on PSGL-1 on the adherent monocytes. These studies document that secondary interactions between monocytes, mediated by PSGL-1, are crucial for monocyte initial attachment, rolling, and accumulation on activated endothelium under laminar shear flow." @default.
• W4313347851 created "2023-01-06" @default.
• W4313347851 creator A5021888249 @default.
• W4313347851 creator A5033954727 @default.
• W4313347851 creator A5061288447 @default.
• W4313347851 creator A5067645113 @default.
• W4313347851 creator A5072998974 @default.
• W4313347851 creator A5085318416 @default.
• W4313347851 date "1998-09-01" @default.
• W4313347851 modified "2023-10-16" @default.
• W4313347851 title "Important Contributions of P-Selectin Glycoprotein Ligand-1-Mediated Secondary Capture to Human Monocyte Adhesion to P-Selectin, E-Selectin, and TNF-α-Activated Endothelium Under Flow In Vitro" @default.
• W4313347851 cites W1492148196 @default.
• W4313347851 cites W1492387747 @default.
• W4313347851 cites W1516595608 @default.
• W4313347851 cites W1537188001 @default.
• W4313347851 cites W1538469124 @default.
• W4313347851 cites W1564398150 @default.
• W4313347851 cites W1580839899 @default.
• W4313347851 cites W1592846365 @default.
• W4313347851 cites W1820868233 @default.
• W4313347851 cites W1900762885 @default.
• W4313347851 cites W1915556271 @default.
• W4313347851 cites W1935692974 @default.
• W4313347851 cites W1958768935 @default.
• W4313347851 cites W1997196395 @default.
• W4313347851 cites W1997842962 @default.
• W4313347851 cites W2004721490 @default.
• W4313347851 cites W2008515082 @default.
• W4313347851 cites W2023693583 @default.
• W4313347851 cites W2032371793 @default.
• W4313347851 cites W2047916715 @default.
• W4313347851 cites W2055543949 @default.
• W4313347851 cites W2060602170 @default.
• W4313347851 cites W2083217753 @default.
• W4313347851 cites W2096090980 @default.
• W4313347851 cites W2103300312 @default.
• W4313347851 cites W2107681553 @default.
• W4313347851 cites W2122028809 @default.
• W4313347851 cites W2127892958 @default.
• W4313347851 cites W2129638932 @default.
• W4313347851 cites W2136083645 @default.
• W4313347851 cites W2137570167 @default.
• W4313347851 cites W2138623142 @default.
• W4313347851 cites W2148464328 @default.
• W4313347851 cites W2155794844 @default.
• W4313347851 cites W2158782513 @default.
• W4313347851 cites W2162433609 @default.
• W4313347851 cites W2165208698 @default.
• W4313347851 cites W2166207391 @default.
• W4313347851 cites W2262294238 @default.
• W4313347851 cites W2282745969 @default.
• W4313347851 cites W2342095344 @default.
• W4313347851 cites W2409974746 @default.
• W4313347851 cites W2411151957 @default.
• W4313347851 cites W4236778183 @default.
• W4313347851 cites W4245735009 @default.
• W4313347851 cites W54197995 @default.
• W4313347851 doi "https://doi.org/10.4049/jimmunol.161.5.2501" @default.
• W4313347851 hasPublicationYear "1998" @default.
• W4313347851 type Work @default.
• W4313347851 citedByCount "51" @default.
• W4313347851 countsByYear W43133478512012 @default.
• W4313347851 countsByYear W43133478512015 @default.
• W4313347851 countsByYear W43133478512017 @default.
• W4313347851 countsByYear W43133478512019 @default.
• W4313347851 crossrefType "journal-article" @default.
• W4313347851 hasAuthorship W4313347851A5021888249 @default.
• W4313347851 hasAuthorship W4313347851A5033954727 @default.
• W4313347851 hasAuthorship W4313347851A5061288447 @default.
• W4313347851 hasAuthorship W4313347851A5067645113 @default.
• W4313347851 hasAuthorship W4313347851A5072998974 @default.
• W4313347851 hasAuthorship W4313347851A5085318416 @default.
• W4313347851 hasBestOaLocation W43133478511 @default.
• W4313347851 hasConcept C108625454 @default.
• W4313347851 hasConcept C134018914 @default.
• W4313347851 hasConcept C153911025 @default.
• W4313347851 hasConcept C155619193 @default.
• W4313347851 hasConcept C16224149 @default.
• W4313347851 hasConcept C178790620 @default.
• W4313347851 hasConcept C185592680 @default.
• W4313347851 hasConcept C199616788 @default.
• W4313347851 hasConcept C203014093 @default.
• W4313347851 hasConcept C2776992346 @default.
• W4313347851 hasConcept C2779835222 @default.
• W4313347851 hasConcept C2781184567 @default.
• W4313347851 hasConcept C3018697912 @default.
• W4313347851 hasConcept C56701166 @default.
• W4313347851 hasConcept C84416704 @default.
• W4313347851 hasConcept C85789140 @default.
• W4313347851 hasConcept C86803240 @default.
• W4313347851 hasConcept C89560881 @default.
• W4313347851 hasConcept C95444343 @default.
• W4313347851 hasConceptScore W4313347851C108625454 @default.
• W4313347851 hasConceptScore W4313347851C134018914 @default.
• W4313347851 hasConceptScore W4313347851C153911025 @default.
• W4313347851 hasConceptScore W4313347851C155619193 @default.
• W4313347851 hasConceptScore W4313347851C16224149 @default.
• W4313347851 hasConceptScore W4313347851C178790620 @default.

• next