FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313347910> ?p ?o ?g. }

• W4313347910 endingPage "2574" @default.
• W4313347910 startingPage "2569" @default.
• W4313347910 abstract "Abstract N-acetyl-l-cysteine (NAC) is an antioxidant molecule endowed with immunomodulatory properties. To investigate the effect of NAC on the induction phase of T cell responses, we analyzed its action on human dendritic cells (DC) derived from adherent PBMC cultured with IL-4 and granulocyte-macrophage CSF. We first found that NAC inhibited the constitutive as well as the LPS-induced activity of the transcription factor NF-κB. In parallel, NAC was shown to down-regulate the production of cytokines by DC as well as their surface expression of HLA-DR, CD86 (B7-2), and CD40 molecules both at the basal state and upon LPS activation. NAC also inhibited DC responses induced by CD40 engagement. The inhibitory effects of NAC were not due to nonspecific toxicity as neither the viability of DC nor their mannose receptor-mediated endocytosis were modified by NAC. Finally, we found that the addition of NAC to MLR between naive T cells and allogeneic DC resulted in a profound inhibition of alloreactive responses, which could be attributed to a defect of DC as APC-independent T cell responses were not inhibited by NAC. Altogether, our results suggest that NAC might impair the generation of primary immune responses in humans through its inhibitory action on DC." @default.
• W4313347910 created "2023-01-06" @default.
• W4313347910 creator A5010664898 @default.
• W4313347910 creator A5016249576 @default.
• W4313347910 creator A5018767436 @default.
• W4313347910 creator A5056089308 @default.
• W4313347910 creator A5058583608 @default.
• W4313347910 creator A5082636498 @default.
• W4313347910 date "1999-03-01" @default.
• W4313347910 modified "2023-10-17" @default.
• W4313347910 title "<i>N</i>-Acetyl-<scp>l</scp>-Cysteine Inhibits Primary Human T Cell Responses at the Dendritic Cell Level: Association with NF-κB Inhibition" @default.
• W4313347910 cites W119433979 @default.
• W4313347910 cites W1485596855 @default.
• W4313347910 cites W1492063880 @default.
• W4313347910 cites W1516048300 @default.
• W4313347910 cites W1556524491 @default.
• W4313347910 cites W1558065199 @default.
• W4313347910 cites W1563909789 @default.
• W4313347910 cites W1568529372 @default.
• W4313347910 cites W1588826234 @default.
• W4313347910 cites W1602143000 @default.
• W4313347910 cites W1661544713 @default.
• W4313347910 cites W1866642200 @default.
• W4313347910 cites W1969535697 @default.
• W4313347910 cites W1981217700 @default.
• W4313347910 cites W2004405778 @default.
• W4313347910 cites W2005495645 @default.
• W4313347910 cites W2010598639 @default.
• W4313347910 cites W2012744796 @default.
• W4313347910 cites W2028092080 @default.
• W4313347910 cites W2031643961 @default.
• W4313347910 cites W2034751609 @default.
• W4313347910 cites W2038042834 @default.
• W4313347910 cites W2048158801 @default.
• W4313347910 cites W2066560682 @default.
• W4313347910 cites W2066901069 @default.
• W4313347910 cites W2070173212 @default.
• W4313347910 cites W2072930832 @default.
• W4313347910 cites W2077908386 @default.
• W4313347910 cites W2081205921 @default.
• W4313347910 cites W2083525090 @default.
• W4313347910 cites W2088696081 @default.
• W4313347910 cites W2102857621 @default.
• W4313347910 cites W2111695773 @default.
• W4313347910 cites W2117300808 @default.
• W4313347910 cites W2117358055 @default.
• W4313347910 cites W2124376809 @default.
• W4313347910 cites W2140066663 @default.
• W4313347910 cites W2140944306 @default.
• W4313347910 cites W2151892297 @default.
• W4313347910 cites W2155229523 @default.
• W4313347910 cites W2177327503 @default.
• W4313347910 cites W2204123985 @default.
• W4313347910 cites W2397860265 @default.
• W4313347910 cites W4313333674 @default.
• W4313347910 doi "https://doi.org/10.4049/jimmunol.162.5.2569" @default.
• W4313347910 hasPublicationYear "1999" @default.
• W4313347910 type Work @default.
• W4313347910 citedByCount "124" @default.
• W4313347910 countsByYear W43133479102012 @default.
• W4313347910 countsByYear W43133479102013 @default.
• W4313347910 countsByYear W43133479102014 @default.
• W4313347910 countsByYear W43133479102015 @default.
• W4313347910 countsByYear W43133479102016 @default.
• W4313347910 countsByYear W43133479102017 @default.
• W4313347910 countsByYear W43133479102018 @default.
• W4313347910 countsByYear W43133479102019 @default.
• W4313347910 countsByYear W43133479102023 @default.
• W4313347910 crossrefType "journal-article" @default.
• W4313347910 hasAuthorship W4313347910A5010664898 @default.
• W4313347910 hasAuthorship W4313347910A5016249576 @default.
• W4313347910 hasAuthorship W4313347910A5018767436 @default.
• W4313347910 hasAuthorship W4313347910A5056089308 @default.
• W4313347910 hasAuthorship W4313347910A5058583608 @default.
• W4313347910 hasAuthorship W4313347910A5082636498 @default.
• W4313347910 hasBestOaLocation W43133479101 @default.
• W4313347910 hasConcept C1491633281 @default.
• W4313347910 hasConcept C153911025 @default.
• W4313347910 hasConcept C154317977 @default.
• W4313347910 hasConcept C167672396 @default.
• W4313347910 hasConcept C170493617 @default.
• W4313347910 hasConcept C185592680 @default.
• W4313347910 hasConcept C202751555 @default.
• W4313347910 hasConcept C203014093 @default.
• W4313347910 hasConcept C2776090121 @default.
• W4313347910 hasConcept C2778170410 @default.
• W4313347910 hasConcept C2781101188 @default.
• W4313347910 hasConcept C28005876 @default.
• W4313347910 hasConcept C39347974 @default.
• W4313347910 hasConcept C53227056 @default.
• W4313347910 hasConcept C55493867 @default.
• W4313347910 hasConcept C86803240 @default.
• W4313347910 hasConcept C8891405 @default.
• W4313347910 hasConcept C95444343 @default.
• W4313347910 hasConceptScore W4313347910C1491633281 @default.
• W4313347910 hasConceptScore W4313347910C153911025 @default.
• W4313347910 hasConceptScore W4313347910C154317977 @default.
• W4313347910 hasConceptScore W4313347910C167672396 @default.

• next