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• W4313347911 abstract "Abstract As previously reported, blood-stage Plasmodium chabaudi AS malaria is lethal by days 10–12 postinfection in susceptible A/J mice that mount an early, predominantly Th2 response. In contrast, resistant C57BL/6 (B6) mice clear the infection by 4 wk with an early Th1 response. In this study, we analyzed in vivo production of IL-12, a potent Th1-inducing cytokine, during the first 5 days after P. chabaudi AS infection in these mice. By day 2, serum IL-12 p70 levels were significantly increased in B6 mice over basal levels and were also significantly higher compared with A/J mice that showed no significant changes in serum p70 levels after infection. Splenectomy of resistant B6 mice before infection demonstrated that the spleen is the major source of systemic IL-12 in these hosts. Splenic mRNA levels of both p40 and p35 were significantly higher in A/J mice; however, the ratios of p40/p35 mRNA levels were similarly up-regulated in both strains. Furthermore, B6 but not A/J mice showed significant up-regulation of splenic IL-12R β2 mRNA over basal levels by days 3 and 4, coincident with sustained up-regulation of splenic IFN-γ mRNA levels on days 3–5. However, IL-12R β1 mRNA levels in the spleen were similarly up-regulated in both mouse strains by day 3. Taken together, these data suggest that high systemic IL-12 production, accompanied by an early and sustained up-regulation of both IL-12R β1 and β2 mRNA levels in the spleen, as occurs in resistant B6 mice, appears to preferentially induce protective Th1 responses against blood-stage malaria." @default.
• W4313347911 created "2023-01-06" @default.
• W4313347911 creator A5041640024 @default.
• W4313347911 creator A5053290087 @default.
• W4313347911 date "1999-02-01" @default.
• W4313347911 modified "2023-10-12" @default.
• W4313347911 title "In Vivo IL-12 Production and IL-12 Receptors β1 and β2 mRNA Expression in the Spleen Are Differentially Up-Regulated in Resistant B6 and Susceptible A/J Mice During Early Blood-Stage<i>Plasmodium chabaudi</i>AS Malaria" @default.
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• W4313347911 doi "https://doi.org/10.4049/jimmunol.162.3.1582" @default.
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