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- W4313347992 abstract "Abstract Genomic DNA methylation patterns influence the development and maintenance of function during cellular differentiation. Methylation of regulatory sequences can have long-lasting effects on gene expression if inherited in an epigenetic manner. Recent work suggests that DNA methylation has a regulatory role in differential cytokine gene expression in primary T lymphocytes. Here we show, by clonal lineage analysis, that methylation patterns in the IFN-γ promoter exhibit long term faithful inheritance in CD44highCD8+ T cells and their progeny, through 16 cell divisions and a clonal expansion of 5 orders of magnitude. Moreover, the demethylated IFN-γ promoter is faithfully inherited following the withdrawal of T cell stimulation and the loss of detectable IFN-γ mRNA, consistent with passive rather than active maintenance mechanisms. This represents a form of stable cellular memory, of defined epigenetic characteristics, that may contribute to the maintenance of T cell cytokine expression patterns and T cell memory." @default.
- W4313347992 created "2023-01-06" @default.
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- W4313347992 date "1999-05-01" @default.
- W4313347992 modified "2023-10-17" @default.
- W4313347992 title "Cutting Edge: Stable Epigenetic Inheritance of Regional IFN-γ Promoter Demethylation in CD44highCD8+ T Lymphocytes" @default.
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- W4313347992 doi "https://doi.org/10.4049/jimmunol.162.9.5053" @default.
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