FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313348013> ?p ?o ?g. }

• W4313348013 endingPage "3044" @default.
• W4313348013 startingPage "3037" @default.
• W4313348013 abstract "Abstract The trafficking of lymphocyte populations is a complex process controlled by a vast array of molecules. In this process, cells must be able to sense small changes in chemoattractant gradients. Migration through a chemotactic gradient probably employs an on-off mechanism in which chemokine receptor desensitization, internalization, and recycling may be important steps. This multistep process requires the coordinated action of many factors, including G protein-coupled receptor kinases, arrestins, clathrin, and GTP-hydrolyzing proteins such as dynamin. In this report, we show that RANTES and its derivative, aminooxypentane (AOP)-RANTES, a potent RANTES antagonist as well as an inhibitor of HIV-1 infection, both promote CCR5 desensitization involving G protein-coupled receptor kinases-2 and β-arrestin equally well. An important difference between the two molecules is that (AOP)-RANTES is more efficient than RANTES in promoting Ser/Thr phosphorylation of the receptor and association of G protein-coupled receptor kinases-2, β-arrestin, and clathrin to the CCR5. After stimulation with either ligand, we observe rapid, transient association of dynamin to CCR5, implicating this protein in receptor sensitization, but this association is faster and longer-lasting following (AOP)-RANTES stimulation. In summary, we show that chemokine receptor internalization takes place through the formation of clathrin vesicles and involves dynamin activity. We provide compelling evidence that the differences between RANTES and (AOP)-RANTES in Gαi activation condition subsequent signaling events, including internalization and receptor recycling." @default.
• W4313348013 created "2023-01-06" @default.
• W4313348013 creator A5007643060 @default.
• W4313348013 creator A5011127415 @default.
• W4313348013 creator A5012847732 @default.
• W4313348013 creator A5051411928 @default.
• W4313348013 creator A5051610763 @default.
• W4313348013 date "1999-09-15" @default.
• W4313348013 modified "2023-10-18" @default.
• W4313348013 title "Characterization of RANTES- and Aminooxypentane-RANTES- Triggered Desensitization Signals Reveals Differences in Recruitment of the G Protein-Coupled Receptor Complex" @default.
• W4313348013 cites W1504684037 @default.
• W4313348013 cites W1505938433 @default.
• W4313348013 cites W1548455476 @default.
• W4313348013 cites W1593164578 @default.
• W4313348013 cites W1602835962 @default.
• W4313348013 cites W1846247956 @default.
• W4313348013 cites W1938724940 @default.
• W4313348013 cites W1973724657 @default.
• W4313348013 cites W1975386197 @default.
• W4313348013 cites W1979669507 @default.
• W4313348013 cites W1980674121 @default.
• W4313348013 cites W1982760200 @default.
• W4313348013 cites W1984811742 @default.
• W4313348013 cites W1990325662 @default.
• W4313348013 cites W1995905351 @default.
• W4313348013 cites W1996183144 @default.
• W4313348013 cites W2000092232 @default.
• W4313348013 cites W2014211428 @default.
• W4313348013 cites W2020174316 @default.
• W4313348013 cites W2021985622 @default.
• W4313348013 cites W2025929812 @default.
• W4313348013 cites W2027344845 @default.
• W4313348013 cites W2031610113 @default.
• W4313348013 cites W2067964854 @default.
• W4313348013 cites W2079317830 @default.
• W4313348013 cites W2086324605 @default.
• W4313348013 cites W2113354135 @default.
• W4313348013 cites W2114164301 @default.
• W4313348013 cites W2123271369 @default.
• W4313348013 cites W2131058276 @default.
• W4313348013 cites W2154319486 @default.
• W4313348013 cites W2160262946 @default.
• W4313348013 cites W4211264883 @default.
• W4313348013 doi "https://doi.org/10.4049/jimmunol.163.6.3037" @default.
• W4313348013 hasPublicationYear "1999" @default.
• W4313348013 type Work @default.
• W4313348013 citedByCount "36" @default.
• W4313348013 countsByYear W43133480132013 @default.
• W4313348013 countsByYear W43133480132014 @default.
• W4313348013 countsByYear W43133480132015 @default.
• W4313348013 countsByYear W43133480132018 @default.
• W4313348013 countsByYear W43133480132021 @default.
• W4313348013 crossrefType "journal-article" @default.
• W4313348013 hasAuthorship W4313348013A5007643060 @default.
• W4313348013 hasAuthorship W4313348013A5011127415 @default.
• W4313348013 hasAuthorship W4313348013A5012847732 @default.
• W4313348013 hasAuthorship W4313348013A5051411928 @default.
• W4313348013 hasAuthorship W4313348013A5051610763 @default.
• W4313348013 hasBestOaLocation W43133480131 @default.
• W4313348013 hasConcept C12823836 @default.
• W4313348013 hasConcept C13373296 @default.
• W4313348013 hasConcept C135285700 @default.
• W4313348013 hasConcept C139770010 @default.
• W4313348013 hasConcept C156407911 @default.
• W4313348013 hasConcept C170493617 @default.
• W4313348013 hasConcept C185592680 @default.
• W4313348013 hasConcept C28005876 @default.
• W4313348013 hasConcept C33235085 @default.
• W4313348013 hasConcept C54166955 @default.
• W4313348013 hasConcept C55493867 @default.
• W4313348013 hasConcept C62478195 @default.
• W4313348013 hasConcept C63162447 @default.
• W4313348013 hasConcept C86803240 @default.
• W4313348013 hasConcept C95444343 @default.
• W4313348013 hasConceptScore W4313348013C12823836 @default.
• W4313348013 hasConceptScore W4313348013C13373296 @default.
• W4313348013 hasConceptScore W4313348013C135285700 @default.
• W4313348013 hasConceptScore W4313348013C139770010 @default.
• W4313348013 hasConceptScore W4313348013C156407911 @default.
• W4313348013 hasConceptScore W4313348013C170493617 @default.
• W4313348013 hasConceptScore W4313348013C185592680 @default.
• W4313348013 hasConceptScore W4313348013C28005876 @default.
• W4313348013 hasConceptScore W4313348013C33235085 @default.
• W4313348013 hasConceptScore W4313348013C54166955 @default.
• W4313348013 hasConceptScore W4313348013C55493867 @default.
• W4313348013 hasConceptScore W4313348013C62478195 @default.
• W4313348013 hasConceptScore W4313348013C63162447 @default.
• W4313348013 hasConceptScore W4313348013C86803240 @default.
• W4313348013 hasConceptScore W4313348013C95444343 @default.
• W4313348013 hasIssue "6" @default.
• W4313348013 hasLocation W43133480131 @default.
• W4313348013 hasOpenAccess W4313348013 @default.
• W4313348013 hasPrimaryLocation W43133480131 @default.
• W4313348013 hasRelatedWork W2009182611 @default.
• W4313348013 hasRelatedWork W2016983159 @default.
• W4313348013 hasRelatedWork W2149456372 @default.
• W4313348013 hasRelatedWork W2157576915 @default.
• W4313348013 hasRelatedWork W3019276455 @default.

• next