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- W4313348022 abstract "Abstract IFN-γ is a key regulatory cytokine of the immune system. Reporter transgenic mice expressing the luciferase gene under the control of separate TCR-response elements (TCR-RE) from the IFN-γ promoter or expressing the green fluorescent protein gene under the control of an IFN-γ “minigene” were employed to explore the basis for IL-12 regulation of IFN-γ gene transcription. In the absence of TCR stimulation, IL-12 did not activate the TCR-REs but did induce green fluorescent protein expression. TCR plus IL-12R stimulation of effector Th cells resulted in: 1) enhanced activation of the proximal, but not the distal, TCR-RE, and 2) increased induction of cJun-proximal TCR-RE complexes and c-Jun protein expression. Overexpression of cJun, but not cFos, increased activity of the proximal TCR-RE in T cells. These results suggest that IL-12R signaling affects IFN-γ gene transcription by at least two separate mechanisms; IL-12R signaling without TCR signaling targets promoter regions outside of the ∼100-bp IFN-γ TCR-RE, and IL-12R signaling also stimulates TCR-induced activity of the proximal TCR-RE." @default.
- W4313348022 created "2023-01-06" @default.
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- W4313348022 date "1999-07-15" @default.
- W4313348022 modified "2023-10-11" @default.
- W4313348022 title "TCR and IL-12 Receptor Signals Cooperate to Activate an Individual Response Element in the IFN-γ Promoter in Effector Th Cells" @default.
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- W4313348022 doi "https://doi.org/10.4049/jimmunol.163.2.728" @default.
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