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W4313348039 startingPage "2089" @default.
W4313348039 abstract "Abstract The interaction of human anaphylatoxin C4a with the guinea pig (gp) and human (hu) C3a receptors (C3aR) was analyzed using human rC4a, which exhibited C4a-specific activity on guinea pig platelets. A gpC3aR of 475 residues with a large second extracellular loop and a peptide sequence ∼60% identical to the huC3aR was isolated from a genomic DNA library and found to be expressed in guinea pig heart, lung, and spleen. HEK-293 cells cotransfected with this clone, and a cDNA encoding Gα-16 specifically bound (Kd = 1.6 ± 0.7 nM) and responded functionally to C3a with an intracellular calcium mobilization (ED50 = 0.18 ± 0.02 nM). Human rC4a weakly bound to both the hu- and gpC3aR (IC50 > 1 μM). However, only HEK-293 cells expressing the gpC3aR responded functionally to rC4a (ED50 = 8.7 ± 0.52 nM), while cells expressing the huC3aR did not (c ≤ 1 μM). Thus, through an interaction with the C3aR, huC4a may elicit anaphylatoxic effects in guinea pigs but not in man." @default.
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W4313348039 date "1998-09-01" @default.
W4313348039 modified "2023-10-01" @default.
W4313348039 title "Cutting Edge: Human Anaphylatoxin C4a Is a Potent Agonist of the Guinea Pig But Not the Human C3a Receptor" @default.
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W4313348039 doi "https://doi.org/10.4049/jimmunol.161.5.2089" @default.
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