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• W4313348085 endingPage "4542" @default.
• W4313348085 startingPage "4535" @default.
• W4313348085 abstract "Abstract This study was undertaken to evaluate the role of CD14 and complement receptors type 3 (CR3) and 4 (CR4) in mediating TNF release and NF-κB activation induced by LPS and cell wall preparations from group B streptococci type III (GBS). LPS and GBS caused TNF secretion from human monocytes in a CD14-dependent manner, and soluble CD14, LPS binding protein, or their combination potentiated both LPS- and GBS-induced activities. Blocking of either CD14 or CD18, the common β-subunit of CR3 and CR4, decreased GBS-induced TNF release, while LPS-mediated TNF production was inhibited by anti-CD14 mAb only. Chinese hamster ovary cell transfectants (CHO) that express human CD14 (CHO/CD14) responded to both LPS and GBS with NF-κB translocation, which was inhibited by anti-CD14 mAb and enhanced by LPS binding protein. While LPS showed fast kinetics of NF-κB activation in CHO/CD14 cells, a slower NF-κB response was induced by GBS. LPS also activated NF-κB in CHO cells transfected with either human CR3 or CR4 cDNA, although responses were delayed and weaker than those of CHO/CD14 cells. In contrast to LPS, GBS failed to induce NF-κB in CHO/CR3 or CHO/CR4 cells. Both C3H/OuJ (Lpsn) and C3H/HeJ (Lpsd) mouse peritoneal macrophages responded to GBS with TNF production and NF-κB translocation, whereas LPS was active only in C3H/OuJ macrophages. Thus, LPS and GBS differentially involve CD14 and CR3 or CR4 for signaling NF-κB activation in CHO cells and TNF release in human monocytes, and engage a different set of receptors and/or intracellular signaling pathways in mouse macrophages." @default.
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• W4313348085 date "1998-05-01" @default.
• W4313348085 modified "2023-10-17" @default.
• W4313348085 title "Involvement of CD14 and Complement Receptors CR3 and CR4 in Nuclear Factor-κB Activation and TNF Production Induced by Lipopolysaccharide and Group B Streptococcal Cell Walls" @default.
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• W4313348085 doi "https://doi.org/10.4049/jimmunol.160.9.4535" @default.
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