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- W4313348086 abstract "Abstract The dissociation by freezing of diphtheria toxin-antitoxin mixtures, with consequent increase in toxicity, was first reported in 1924 by White and Robinson (5). Kirkbride and Dow (3), in an article published simultaneously, stated that, under their experimental conditions, they were unable to produce this phenomenon. Anderson and Leonard (1) succeeded in bringing about such a dissociation, but only in experimental mixtures differing from those ordinarily employed for active immunization against diphtheria. Following the appearance of these papers, Glenny, Pope, Waddington and Wallace (2) suggested that an increased phenol concentration, brought about as the mixtures freeze, is the cause of the increased toxicity and that the discordant results reported “are due to the amount of protein present and other factors influencing the relative degree of destruction of antitoxin or of toxin by the local concentration of phenol that occurs when these mixtures are frozen.”" @default.
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- W4313348086 date "1928-07-01" @default.
- W4313348086 modified "2023-09-26" @default.
- W4313348086 title "Effect of Exposure to Low Temperatures on Diphtheria Toxin-Antitoxin Mixtures" @default.
- W4313348086 doi "https://doi.org/10.4049/jimmunol.15.4.381" @default.
- W4313348086 hasPublicationYear "1928" @default.
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