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- W4313348148 abstract "Abstract During the CD4-CD8- double negative (DN) stage of T cell development, the cells express TCRβ for the first time. TCRβ+ cells activate signaling pathways that promote survival, proliferation, and differentiation, but the receptors required for these signals are unknown. While Notch and IL-7 are critical for early T cell development, their function in TCRβ-expressing DN and immature single positive (ISP) CD8+ thymocytes are unclear. Here, we cultured purified DN3E (CD44-CD25hi), DN3L (CD44-CD25lo), DN4 (CD44-CD25-) and ISP CD8+ thymocytes with OP9 cells that express either the Notch ligand Delta-like 1 (DL1) or control protein. To some samples, IL-7 was also added. DN and ISP thymocytes were able to differentiate into CD4+CD8+ double positive (DP) thymocytes independently of Notch and IL-7. However, Notch promoted the proliferation and survival of the thymocytes, whereas IL-7 promoted survival and slowed differentiation. These data demonstrate that Notch and IL-7 continue to function beyond the time at which TCRβ is expressed and regulate survival, proliferation, and differentiation of TCRβ-expressing thymocytes. This research is supported by the America Cancer Society grant RSG-08-182-01-LIB." @default.
- W4313348148 created "2023-01-06" @default.
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- W4313348148 date "2009-04-01" @default.
- W4313348148 modified "2023-09-25" @default.
- W4313348148 title "Notch and IL-7 regulate cell fate decisions in TCRβ+ DN and ISP thymocytes (85.10)" @default.
- W4313348148 doi "https://doi.org/10.4049/jimmunol.182.supp.85.10" @default.
- W4313348148 hasPublicationYear "2009" @default.
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