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- W4313348162 abstract "Abstract T cell DNA demethylation contributes to human lupus. The mechanisms causing demethylation are incompletely understood. DNA methylation depends on DNA methyltransferase activity and S-adenosylmethionine (SAM), and is inhibited by S-adenosylhomocysteine (SAH). SAM levels are determined by Zn, B2, B6, B12, folate, Met and choline, and SAH by homocysteine (Hcy). We hypothesized that decreasing nutrients required for SAM or increasing Hcy increases expression of methylation sensitive T cell genes, and that levels of these nutrients are abnormal in lupus patients. PHA stimulated T cells were cultured in custom media with variable concentrations of each nutrient, and effects on methylation sensitive gene expression (CD70, KIR and perforin) compared by flow cytometry. T cells cultured in media adjusted to median serum levels of each nutrient overexpressed all methylation sensitive genes relative to complete media. Increasing Hcy caused further increases in CD70 while increasing folate or B6 concentrations suppressed perforin overexpression. Lupus patients had lower B6 and Zn levels, and higher Hcy levels than controls. These results suggest that a poor diet may contribute to abnormal T cell gene expression in lupus, and that dietary supplementation may have a beneficial effect." @default.
- W4313348162 created "2023-01-06" @default.
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- W4313348162 date "2009-04-01" @default.
- W4313348162 modified "2023-10-04" @default.
- W4313348162 title "Diet and DNA methylation in lupus (50.29)" @default.
- W4313348162 doi "https://doi.org/10.4049/jimmunol.182.supp.50.29" @default.
- W4313348162 hasPublicationYear "2009" @default.
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