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- W4313348220 endingPage "90.11" @default.
- W4313348220 startingPage "90.11" @default.
- W4313348220 abstract "Abstract The differentiation of T cells along different lineages is central to the control of immunity. In order to investigate the role of PKCλ/ι, a member of atypical protein kinase C, in T cell function, we used a conditional gene knockout system by loxP-Cre recombination to selectively delete PKCλ/ι in activated T cells. With this system, we found that PKCλ/ι was necessary for Th2 cytokine production. Upon anti-CD3 plus anti-CD28 stimulation, IL-4 and IL-13 production from CD4+ T cells was significantly reduced in conditional KO mice as compared to their WT littermates. However, PKCλ/ι was not involved in Th1 cytokine secretion. T cell proliferation was impaired in conditional PKCλ/ι KO mice. Furthermore, deficiency of PKCλ/ι inhibited OVA-induced allergic airway inflammation in vivo. Our data demonstrated that the activation of the transcription factors NFAT and NF-¿B was impaired in PKCλ/ι-deficient activated T cells. In addition, we presented genetic knockout evidence in ex vivo experiments with primary T cells that PKCλ/ι was critical for the control of cell polarity during T cell activation. Therefore, PKCλ/ι emerges as a critical regulator of Th2 cell activation." @default.
- W4313348220 created "2023-01-06" @default.
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- W4313348220 date "2009-04-01" @default.
- W4313348220 modified "2023-09-26" @default.
- W4313348220 title "Role of the PKCλ/ι in Th2 establishment and airway hyperresponsiveness (90.11)" @default.
- W4313348220 doi "https://doi.org/10.4049/jimmunol.182.supp.90.11" @default.
- W4313348220 hasPublicationYear "2009" @default.
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