Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313348229> ?p ?o ?g. }
Showing items 1 to 58 of
58
with 100 items per page.
- W4313348229 endingPage "35.5" @default.
- W4313348229 startingPage "35.5" @default.
- W4313348229 abstract "Abstract Human mast cells play a role in the pathogenesis of inflammatory airway diseases. We have reported that CSE increased IL-6 and IL-8 production in IL-1beta activated human mast cells (HMC-1). Baicalein (BAI) has been shown to have anti-inflammatory properties. This study aimed to examine the effect of BAI on IL-6 and IL-8 production in HMC-1. Two ml of HMC-1 at 1 x 106 cells/ml were cultured either with or without IL-1beta (10 ng/ml), and in the presence or absence of mainstream (Ms) or sidestream (Ss) CSE (0.25 mg/ml or 0.125 mg/ml), and BAI (30 μM). Treated HMC-1 were incubated for 24 hours and culture supernatants were collected and analyzed for the levels of IL-6 and IL-8 by ELISA. Both concentrations of Ms and Ss CSE significantly increased production of both IL-6 (p < 0.0001) and IL-8 (p < 0.0005) in IL-1beta activated HMC-1. BAI (30 μm) decreased IL-6 and IL-8 production in the Ms CSE (0.25 mg/ml) + IL-1beta treated HMC-1 culture from 2615 ± 38 to 251 ± 19 pg/ml (p < 0.0000001) and from 583 ± 37 to 179 ± 7 pg/ml (p < 0.0005), respectively. A similar inhibitory effect of BAI was also observed in the Ss CSE + IL-1beta treated HMC-1 culture. Our results show that BAI inhibits the enhancing effects of CSE on inflammatory cytokine production in IL-1beta activated mast cells. It suggests that BAI may be a novel candidate for treatment of smoking related inflammatory airway disease (Supported by the Ruth R. Harris Endowment and RDC of ETSU)." @default.
- W4313348229 created "2023-01-06" @default.
- W4313348229 creator A5014972964 @default.
- W4313348229 creator A5015433067 @default.
- W4313348229 creator A5025406344 @default.
- W4313348229 creator A5026548387 @default.
- W4313348229 creator A5028870068 @default.
- W4313348229 creator A5083088365 @default.
- W4313348229 date "2010-04-01" @default.
- W4313348229 modified "2023-09-30" @default.
- W4313348229 title "Baicalein inhibits the enhancing effects of cigarette smoke extract (CSE) on inflammatory cytokine production in IL-1beta activated mast cells (35.5)" @default.
- W4313348229 doi "https://doi.org/10.4049/jimmunol.184.supp.35.5" @default.
- W4313348229 hasPublicationYear "2010" @default.
- W4313348229 type Work @default.
- W4313348229 citedByCount "0" @default.
- W4313348229 crossrefType "journal-article" @default.
- W4313348229 hasAuthorship W4313348229A5014972964 @default.
- W4313348229 hasAuthorship W4313348229A5015433067 @default.
- W4313348229 hasAuthorship W4313348229A5025406344 @default.
- W4313348229 hasAuthorship W4313348229A5026548387 @default.
- W4313348229 hasAuthorship W4313348229A5028870068 @default.
- W4313348229 hasAuthorship W4313348229A5083088365 @default.
- W4313348229 hasConcept C185592680 @default.
- W4313348229 hasConcept C203014093 @default.
- W4313348229 hasConcept C2778690821 @default.
- W4313348229 hasConcept C2780942790 @default.
- W4313348229 hasConcept C2781466915 @default.
- W4313348229 hasConcept C68324877 @default.
- W4313348229 hasConcept C71924100 @default.
- W4313348229 hasConcept C98274493 @default.
- W4313348229 hasConceptScore W4313348229C185592680 @default.
- W4313348229 hasConceptScore W4313348229C203014093 @default.
- W4313348229 hasConceptScore W4313348229C2778690821 @default.
- W4313348229 hasConceptScore W4313348229C2780942790 @default.
- W4313348229 hasConceptScore W4313348229C2781466915 @default.
- W4313348229 hasConceptScore W4313348229C68324877 @default.
- W4313348229 hasConceptScore W4313348229C71924100 @default.
- W4313348229 hasConceptScore W4313348229C98274493 @default.
- W4313348229 hasIssue "1_Supplement" @default.
- W4313348229 hasLocation W43133482291 @default.
- W4313348229 hasOpenAccess W4313348229 @default.
- W4313348229 hasPrimaryLocation W43133482291 @default.
- W4313348229 hasRelatedWork W2027383039 @default.
- W4313348229 hasRelatedWork W2029966946 @default.
- W4313348229 hasRelatedWork W2032038816 @default.
- W4313348229 hasRelatedWork W2056067227 @default.
- W4313348229 hasRelatedWork W2070463916 @default.
- W4313348229 hasRelatedWork W2108652407 @default.
- W4313348229 hasRelatedWork W2899084033 @default.
- W4313348229 hasRelatedWork W3095812868 @default.
- W4313348229 hasRelatedWork W4313348229 @default.
- W4313348229 hasRelatedWork W4313385027 @default.
- W4313348229 hasVolume "184" @default.
- W4313348229 isParatext "false" @default.
- W4313348229 isRetracted "false" @default.
- W4313348229 workType "article" @default.