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- W4313348239 abstract "Abstract Naïve T cells proliferate in response to lymphopenia and acquire the phenotypic and functional qualities of memory T cells, providing enhanced protection against infection. How well 'memory-like' T cells generated during lymphopenia-induced homeostatic proliferation (HP-memory) differentiate into secondary memory cells and compete with antigen-experienced 'true-memory' cells is unknown. We found that CD8+ HP-memory T cells generated robust responses upon infection and produced a secondary memory population comparable to true-memory cells in the absence of competition. However, when true-memory and HP-memory T cells competed during infection, HP-memory cells contributed less to the effector population, contracted earlier and formed fewer secondary memory cells. Furthermore, HP- and true-memory cells demonstrated aberrant chemokine receptor expression and distinct localization within the spleen during infection, indicating differential access to signals necessary for secondary memory formation. Thus, HP-memory T cells provide protection without compromising the true-memory population. Differences in HP-and true-memory T cells may reveal the basis for competition for limited resources within the memory T cell compartment." @default.
- W4313348239 created "2023-01-06" @default.
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- W4313348239 date "2009-04-01" @default.
- W4313348239 modified "2023-09-27" @default.
- W4313348239 title "Memory-like CD8+ T cells generated during homeostatic proliferation defer to antigen-experienced memory cells (82.18)" @default.
- W4313348239 doi "https://doi.org/10.4049/jimmunol.182.supp.82.18" @default.
- W4313348239 hasPublicationYear "2009" @default.
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