Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313349531> ?p ?o ?g. }
Showing items 1 to 66 of
66
with 100 items per page.
- W4313349531 endingPage "197.3" @default.
- W4313349531 startingPage "197.3" @default.
- W4313349531 abstract "Abstract The autoimmune disease theory explains that autoreactive clones derive from restricted clones either slipped from thymic selection or reactivated from tolerance, which cannot explain varieties of autoantibody exceeding 140 specificities seen in SLE. We instead show that autoreactive clones newly emerge via de novo TCRalpha but not beta revision at periphery from thymus-passed non-autoreactive clones (PLoS ONE 4(12):e8382,2009). This autoreactive autoantibody-inducing CD4 (aiCD4) T cell stimulates B cells to generate autoantibodies and helps to generate CD8 CTL via antigen cross-presentation and cause SLE. We studied how aiCD4 T cell is produced. Methods: Balb/c mice were immunization 8x with staphylococcus enterotoxin B (SEB), signaling molecules and their phosphorylation were assayed using western blot and antibodies. Results: The chromatin of CD4 T cell V,J region was not acetylated/ H3K4me3-lated and open, thereby facilitating the access of RAG1/2. Upon repeated immunization 8x with SBE, RAG1/2 was up-regulated but CD3zeta, ZAP70, LAT, SLP-76, PLCgamma1 and NFAT1/2 were down-regulated in splenic Vbeta8+CD4 T cell. Instead, re-activation of RAG1/2 was inhibited when TCR signal was augmented vice versa by adding PMA+ionomycin, indicating that loss of TCR signal reactivates RAG1/2 at peripheral lymphoid organ in spleen. Conclusion: Weak TCR signaling due to repeated immunization with antigen re-expresses RAG1/2 at periphery to induce aiCD4 T cell and cause SLE." @default.
- W4313349531 created "2023-01-06" @default.
- W4313349531 creator A5015734455 @default.
- W4313349531 creator A5051287732 @default.
- W4313349531 creator A5078160667 @default.
- W4313349531 date "2013-05-01" @default.
- W4313349531 modified "2023-09-27" @default.
- W4313349531 title "Weak TCR signaling due to repeated immunization with antigen is the key for peripheral TCR revision generating aiCD4 T cell: a novel self-organized criticality theory (P4537)" @default.
- W4313349531 doi "https://doi.org/10.4049/jimmunol.190.supp.197.3" @default.
- W4313349531 hasPublicationYear "2013" @default.
- W4313349531 type Work @default.
- W4313349531 citedByCount "0" @default.
- W4313349531 crossrefType "journal-article" @default.
- W4313349531 hasAuthorship W4313349531A5015734455 @default.
- W4313349531 hasAuthorship W4313349531A5051287732 @default.
- W4313349531 hasAuthorship W4313349531A5078160667 @default.
- W4313349531 hasConcept C104317684 @default.
- W4313349531 hasConcept C113646796 @default.
- W4313349531 hasConcept C147483822 @default.
- W4313349531 hasConcept C153911025 @default.
- W4313349531 hasConcept C156695909 @default.
- W4313349531 hasConcept C159654299 @default.
- W4313349531 hasConcept C163764329 @default.
- W4313349531 hasConcept C19317047 @default.
- W4313349531 hasConcept C195616568 @default.
- W4313349531 hasConcept C203014093 @default.
- W4313349531 hasConcept C2776090121 @default.
- W4313349531 hasConcept C54355233 @default.
- W4313349531 hasConcept C86803240 @default.
- W4313349531 hasConcept C8891405 @default.
- W4313349531 hasConcept C95444343 @default.
- W4313349531 hasConceptScore W4313349531C104317684 @default.
- W4313349531 hasConceptScore W4313349531C113646796 @default.
- W4313349531 hasConceptScore W4313349531C147483822 @default.
- W4313349531 hasConceptScore W4313349531C153911025 @default.
- W4313349531 hasConceptScore W4313349531C156695909 @default.
- W4313349531 hasConceptScore W4313349531C159654299 @default.
- W4313349531 hasConceptScore W4313349531C163764329 @default.
- W4313349531 hasConceptScore W4313349531C19317047 @default.
- W4313349531 hasConceptScore W4313349531C195616568 @default.
- W4313349531 hasConceptScore W4313349531C203014093 @default.
- W4313349531 hasConceptScore W4313349531C2776090121 @default.
- W4313349531 hasConceptScore W4313349531C54355233 @default.
- W4313349531 hasConceptScore W4313349531C86803240 @default.
- W4313349531 hasConceptScore W4313349531C8891405 @default.
- W4313349531 hasConceptScore W4313349531C95444343 @default.
- W4313349531 hasIssue "1_Supplement" @default.
- W4313349531 hasLocation W43133495311 @default.
- W4313349531 hasOpenAccess W4313349531 @default.
- W4313349531 hasPrimaryLocation W43133495311 @default.
- W4313349531 hasRelatedWork W1796990215 @default.
- W4313349531 hasRelatedWork W1872459230 @default.
- W4313349531 hasRelatedWork W1922768394 @default.
- W4313349531 hasRelatedWork W1977810547 @default.
- W4313349531 hasRelatedWork W2059923545 @default.
- W4313349531 hasRelatedWork W2060246599 @default.
- W4313349531 hasRelatedWork W2125043176 @default.
- W4313349531 hasRelatedWork W2161246929 @default.
- W4313349531 hasRelatedWork W2313745184 @default.
- W4313349531 hasRelatedWork W2417019234 @default.
- W4313349531 hasVolume "190" @default.
- W4313349531 isParatext "false" @default.
- W4313349531 isRetracted "false" @default.
- W4313349531 workType "article" @default.