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- W4313349554 abstract "Abstract Influenza viruses cause significant annual illness and death in the elderly with recurrent seasonal epidemics and sporadic devastating pandemics. CD8 T cells are crucial for resolving influenza virus infection, can protect from divergent viruses, and are highly correlated with protection in the elderly. Due to its anatomical location, the nasal-associated lymphoid tissue (NALT) is crucial for the induction of the immune response, yet little is known regarding the requirements for optimal immunity at this mucosal site. We demonstrated that the number of antiviral CD8 T cells in the NALT was reduced in the aged. Phenotypic analyses of nasal T cells revealed that the carbohydrate-dependent rolling receptors L-Selectin, P-Selectin glycoprotein ligand-1, and CD44 were differentially expressed on aged T cells. We addressed the hypothesis that the reprogramming of adhesion receptor expression in the aged functionally impacts the migration of virus-specific CD8 T cells to the infected nasal mucosa. We demonstrated that rolling receptors, especially L-Selectin, were crucial for CD8 T cell recruitment to the NALT. Thus, the differential adhesion receptor expression profile on aged CD8 T cells may provide a mechanism that contributes to defective mucosal immunity in the elderly and our provides crucial information for novel strategies for improved nasal vaccines." @default.
- W4313349554 created "2023-01-06" @default.
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- W4313349554 date "2013-05-01" @default.
- W4313349554 modified "2023-10-18" @default.
- W4313349554 title "Altered adhesion receptor expression impairs recruitment of aged T cell to the nasal mucosa in response to influenza virus infection. (P5085)" @default.
- W4313349554 doi "https://doi.org/10.4049/jimmunol.190.supp.129.7" @default.
- W4313349554 hasPublicationYear "2013" @default.
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