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- W4313349557 abstract "Abstract Interferon-γ (IFNγ) has immunostimulatory, immunomodulatory and direct anti-viral properties. Previous studies have demonstrated the importance of IFNγ signaling during the immune response to rabies virus (RABV) as well as other neurotropic viruses. Specifically, IFNγ mRNA expression in the brains of RABV-infected mice correlates with immune effector entry into the brain and virus clearance. To more directly study the effect of IFNγ on the virus host response in the CNS, we constructed three IFNγ-expressing RABV vectors with decreasingly pathogenic backbone structures. We report that intranasal infection of mice with control SPBN is highly pathogenic but similar infection with SPBNγ is not. In addition, IFNγ expression by the attenuated RABV GASγ strain renders it significantly more effective than the highly attenuated GASGAS virus in preventing the death of mice from an otherwise lethal dose of DOG4 RABV when both are simultaneously administered intracranially. Finally, post-exposure treatment (PET) with an intramuscular injection of GASγGAS prevents the generally lethal outcome of intranasal infection of mice with DOG4 RABV and significantly reduces morbidity as compared to other PET RABV strains. Analysis of a variety of parameters of immunity in vivo and in vitro indicates that the protection provided by virus-encoded IFNγ is largely due to its impact on the innate response." @default.
- W4313349557 created "2023-01-06" @default.
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- W4313349557 date "2013-05-01" @default.
- W4313349557 modified "2023-09-26" @default.
- W4313349557 title "The expression of mouse interferon-γ by engineered rabies viruses protects mice from lethal CNS infection through effects on innate immunity. (P6141)" @default.
- W4313349557 doi "https://doi.org/10.4049/jimmunol.190.supp.128.21" @default.
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