Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313349574> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W4313349574 endingPage "130.21" @default.
- W4313349574 startingPage "130.21" @default.
- W4313349574 abstract "Abstract Influenza infection in mice is characterized by waves of recruitment of innate immune cells into the lung. We have previously described TNF-α/iNOS-producing monocytes (TipDC) as promoting the anti-influenza adaptive immune response and contributing to disease pathogenesis. Here, we report the identification of a novel subset of monocytes, distinct from TipDCs and lung resident innate populations, that is recruited into the lung during influenza infection in mice. These monocytes had distinct morphology, phenotypic lineage marker expression (CD8α, CD103, F4/80 and Ly6C etc) and transcriptional profile from TipDCs. CCR2 signaling contributed to the recruitment of this monocyte subset into the lung, but it was not indispensable. They were not found in the lung-draining lymph nodes. Functionally, both these monocytes and TipDC could not stimulate CD4 T cell proliferation, but only this subset of monocytes suppressed CD4 and CD8 T cell proliferation, and they also induced high levels of Th17-associated cytokines from CD4 T cells. Our results highlight the heterogeneity of monocyte populations and their functional roles in anti-viral immunity to influenza infection. This heterogeneity may be harnessed for immune modulation strategies as novel therapeutics for influenza infection." @default.
- W4313349574 created "2023-01-06" @default.
- W4313349574 creator A5009623128 @default.
- W4313349574 creator A5035851025 @default.
- W4313349574 creator A5053084018 @default.
- W4313349574 creator A5055642510 @default.
- W4313349574 creator A5067558632 @default.
- W4313349574 date "2013-05-01" @default.
- W4313349574 modified "2023-10-14" @default.
- W4313349574 title "Functional heterogeneity of monocyte populations during influenza virus infection (P4243)" @default.
- W4313349574 doi "https://doi.org/10.4049/jimmunol.190.supp.130.21" @default.
- W4313349574 hasPublicationYear "2013" @default.
- W4313349574 type Work @default.
- W4313349574 citedByCount "0" @default.
- W4313349574 crossrefType "journal-article" @default.
- W4313349574 hasAuthorship W4313349574A5009623128 @default.
- W4313349574 hasAuthorship W4313349574A5035851025 @default.
- W4313349574 hasAuthorship W4313349574A5053084018 @default.
- W4313349574 hasAuthorship W4313349574A5055642510 @default.
- W4313349574 hasAuthorship W4313349574A5067558632 @default.
- W4313349574 hasConcept C12823836 @default.
- W4313349574 hasConcept C13373296 @default.
- W4313349574 hasConcept C136449434 @default.
- W4313349574 hasConcept C159047783 @default.
- W4313349574 hasConcept C167672396 @default.
- W4313349574 hasConcept C193419808 @default.
- W4313349574 hasConcept C203014093 @default.
- W4313349574 hasConcept C206615009 @default.
- W4313349574 hasConcept C2522874641 @default.
- W4313349574 hasConcept C2776090121 @default.
- W4313349574 hasConcept C2777546802 @default.
- W4313349574 hasConcept C2779341262 @default.
- W4313349574 hasConcept C2780942790 @default.
- W4313349574 hasConcept C2781184567 @default.
- W4313349574 hasConcept C86803240 @default.
- W4313349574 hasConcept C8891405 @default.
- W4313349574 hasConceptScore W4313349574C12823836 @default.
- W4313349574 hasConceptScore W4313349574C13373296 @default.
- W4313349574 hasConceptScore W4313349574C136449434 @default.
- W4313349574 hasConceptScore W4313349574C159047783 @default.
- W4313349574 hasConceptScore W4313349574C167672396 @default.
- W4313349574 hasConceptScore W4313349574C193419808 @default.
- W4313349574 hasConceptScore W4313349574C203014093 @default.
- W4313349574 hasConceptScore W4313349574C206615009 @default.
- W4313349574 hasConceptScore W4313349574C2522874641 @default.
- W4313349574 hasConceptScore W4313349574C2776090121 @default.
- W4313349574 hasConceptScore W4313349574C2777546802 @default.
- W4313349574 hasConceptScore W4313349574C2779341262 @default.
- W4313349574 hasConceptScore W4313349574C2780942790 @default.
- W4313349574 hasConceptScore W4313349574C2781184567 @default.
- W4313349574 hasConceptScore W4313349574C86803240 @default.
- W4313349574 hasConceptScore W4313349574C8891405 @default.
- W4313349574 hasIssue "1_Supplement" @default.
- W4313349574 hasLocation W43133495741 @default.
- W4313349574 hasOpenAccess W4313349574 @default.
- W4313349574 hasPrimaryLocation W43133495741 @default.
- W4313349574 hasRelatedWork W1574628415 @default.
- W4313349574 hasRelatedWork W1975418102 @default.
- W4313349574 hasRelatedWork W2103515427 @default.
- W4313349574 hasRelatedWork W2141330728 @default.
- W4313349574 hasRelatedWork W2188294308 @default.
- W4313349574 hasRelatedWork W2476770332 @default.
- W4313349574 hasRelatedWork W2610389334 @default.
- W4313349574 hasRelatedWork W2946615038 @default.
- W4313349574 hasRelatedWork W2986423947 @default.
- W4313349574 hasRelatedWork W3209390153 @default.
- W4313349574 hasVolume "190" @default.
- W4313349574 isParatext "false" @default.
- W4313349574 isRetracted "false" @default.
- W4313349574 workType "article" @default.