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- W4313349594 abstract "Abstract Inflammasome is emerging as a central regulator of inflammatory immune responses. Nlrp3 inflammasome has been shown to be critical for intestinal homeostasis and inflammation using chemical dextran sodium sulfate -induced colitis model. However, the roles of inflammasome in other more natural models of colitis such as colitis induced by enteric bacteria (e.g., Citrobacter rodentium) are not well known. Our study identified that mice lacking the inflammasome components Nlrp3, Nlrc4 and Caspase-1 were highly susceptible to C. rodentium-induced colitis, demonstrated by more weight loss, higher bacterial burden and more severe histological lesions, in comparison to wild-type (WT) mice. Inflammasome-deficient mice displayed much higher infiltration of neutrophil and macrophage into spleen and colon. In addition, in comparison to WT mice, Caspase 1-deficient mice had higher percentage of active T cell that secret more IFN-γ, which might significantly contribute to the elevated inflammation in intestinal mucosa. We also identified that inflammasome-mediated production of IL-1β and IL-18 are critical for host defense against C. rodentium infection. Dissect the mechanisms how these inflammatory cytokines regulate host immune responses to enteric pathogens will be of great interest to the understanding of inflammatory bowel disease pathogenesis." @default.
- W4313349594 created "2023-01-06" @default.
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- W4313349594 date "2013-05-01" @default.
- W4313349594 modified "2023-09-30" @default.
- W4313349594 title "Inflammasome regulates host immune responses to enteric pathogen (P4237)" @default.
- W4313349594 doi "https://doi.org/10.4049/jimmunol.190.supp.130.18" @default.
- W4313349594 hasPublicationYear "2013" @default.
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