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- W4313349623 abstract "Abstract Dendritic cells (DCs) specialize in antigen (Ag) sampling and presentation and are critical for promoting T cell-mediated immune responses. DCs are composed of multiple subsets with divergent functional capabilities, with lymph node (LN)-resident CD8+ vs. CD11b+ DC preferentially processing captured Ags for MHC-I vs. MHC-II presentation, respectively. Utilizing a novel microscopy method, “Histo-Cytometry,” we have recently found that these subsets reside in differential spatial micro-compartments in murine LN, with preferential but not exclusive localization of CD8+ DCs to the central T cell zone and the CD11b+ DCs to the LN periphery. Here, we show that DC spatial positioning has profound functional effects on DC-mediated Ag capture and downstream MHC processing after protein immunization. Specifically, poor Ag penetration deep inside the LN paracortex led to decreased Ag sampling by the centrally localized CD8+ DCs and absence of CD8+ T cell responses at low levels of immunized Ag, as compared to the more effective Ag capture by peripheral CD11b+ DC and CD4+ T cell priming. Moreover, DC subset regionalization directly influenced the location of early CD8+ vs. CD4+ T cell activation, with centrally localized CD8+ T cell vs. predominantly peripheral CD4+ T cell priming. Collectively, these findings indicate that spatial organization by DC subsets creates micro-anatomical domains with specialized functional capacities affecting the development of cell-mediated immunity." @default.
- W4313349623 created "2023-01-06" @default.
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- W4313349623 date "2013-05-01" @default.
- W4313349623 modified "2023-10-01" @default.
- W4313349623 title "The role of lymphoid micro-architecture in dendritic cell-mediated antigen capture and initiation of cellular adaptive immunity (P5200)" @default.
- W4313349623 doi "https://doi.org/10.4049/jimmunol.190.supp.198.7" @default.
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