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- W4313349626 abstract "Abstract Dendritic cells (DCs) are recruited to sites of infection where they process antigens and migrate to the draining lymph node in order to trigger specific T cell responses. In the C57BL/6J mouse model of cutaneous Leishmaniasis, monocyte-derived dendritic cells were shown to initiate the protective Th1 response against the parasite. Junctional adhesion molecule C (JAM-C), a tight junction protein expressed on endothelial cells and fibroblasts, was described in the past few years to control leukocyte migration during inflammation. Here we showed that targeting JAM-C with a monoclonal antibody improves the development of cutaneous lesions after Leishmania major infection. Indeed, we observed a two-fold increase in the number of neutrophils and monocyte-derived dendritic cells recruited one-day post infection without affecting the number and function of resident macrophages. In addition, analysis of the draining lymph node populations at several time points after infection showed a higher number of migratory dendritic cells. This enhanced antigen presenting cells recruitment boosted the activation of the Th1 response as shown by the increased number of IFN-γ-producing CD4 T cells. Overall, targeting JAM-C could represent a new way to enhance T cell response in Leishmaniasis as well as other infection diseases." @default.
- W4313349626 created "2023-01-06" @default.
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- W4313349626 date "2013-05-01" @default.
- W4313349626 modified "2023-09-27" @default.
- W4313349626 title "Targeting junctional adhesion molecule C improves the protective Th1 immunity through enhanced dendritic cell recruitment in response to Leishmania major infection (P5101)" @default.
- W4313349626 doi "https://doi.org/10.4049/jimmunol.190.supp.129.15" @default.
- W4313349626 hasPublicationYear "2013" @default.
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