Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313349719> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W4313349719 endingPage "42.24" @default.
- W4313349719 startingPage "42.24" @default.
- W4313349719 abstract "Abstract CD1 molecules are a family of antigen presenting molecules that present lipids and glycolipids for recognition by specialized T cells. The CD1 system has been implicated in microbial infections, autoimmune and allergic disorders, and immunological control of tumors. However, our understanding of its role in human disease remains limited because animal models that resemble the human CD1 system are lacking. Here we report that a severely immune deficient mouse engrafted with human fetal tissues and hematopoietic stem cells develops an intact human CD1 antigen presenting system. Human CD1a, b, c, and d isoforms are highly expressed in the thymic organoid that develops in the engrafted mice, and histological analysis indicates the presence of CD1a+ APCs. Moreover, CD1+ APCs are expressed in peripheral tissues including the spleen and liver, and are capable of presenting bacterial glycolipids to human T cells specific for CD1a, b, or c. Staining with CD1d tetramers detected comparable percentages of human CD1d-restricted T cells in engrafted mice and human blood, and CD1d-restricted T cells isolated from the mice expressed a characteristic Vα24+/Vβ11+ TCR and recognized the glycolipid antigen α-GalCer. These results demonstrate the functional reconstitution of the human CD1 system in a mouse model." @default.
- W4313349719 created "2023-01-06" @default.
- W4313349719 creator A5000815014 @default.
- W4313349719 creator A5001996743 @default.
- W4313349719 creator A5008871183 @default.
- W4313349719 creator A5049956452 @default.
- W4313349719 creator A5053254937 @default.
- W4313349719 creator A5056247914 @default.
- W4313349719 creator A5057915644 @default.
- W4313349719 creator A5060859609 @default.
- W4313349719 creator A5076971195 @default.
- W4313349719 creator A5079424748 @default.
- W4313349719 date "2009-04-01" @default.
- W4313349719 modified "2023-09-26" @default.
- W4313349719 title "An in vivo model of the human CD1 antigen presenting system (42.24)" @default.
- W4313349719 doi "https://doi.org/10.4049/jimmunol.182.supp.42.24" @default.
- W4313349719 hasPublicationYear "2009" @default.
- W4313349719 type Work @default.
- W4313349719 citedByCount "0" @default.
- W4313349719 crossrefType "journal-article" @default.
- W4313349719 hasAuthorship W4313349719A5000815014 @default.
- W4313349719 hasAuthorship W4313349719A5001996743 @default.
- W4313349719 hasAuthorship W4313349719A5008871183 @default.
- W4313349719 hasAuthorship W4313349719A5049956452 @default.
- W4313349719 hasAuthorship W4313349719A5053254937 @default.
- W4313349719 hasAuthorship W4313349719A5056247914 @default.
- W4313349719 hasAuthorship W4313349719A5057915644 @default.
- W4313349719 hasAuthorship W4313349719A5060859609 @default.
- W4313349719 hasAuthorship W4313349719A5076971195 @default.
- W4313349719 hasAuthorship W4313349719A5079424748 @default.
- W4313349719 hasConcept C139563560 @default.
- W4313349719 hasConcept C147483822 @default.
- W4313349719 hasConcept C167672396 @default.
- W4313349719 hasConcept C203014093 @default.
- W4313349719 hasConcept C22222904 @default.
- W4313349719 hasConcept C2776090121 @default.
- W4313349719 hasConcept C2778607024 @default.
- W4313349719 hasConcept C2780931953 @default.
- W4313349719 hasConcept C37386791 @default.
- W4313349719 hasConcept C67662055 @default.
- W4313349719 hasConcept C86803240 @default.
- W4313349719 hasConcept C8891405 @default.
- W4313349719 hasConcept C95444343 @default.
- W4313349719 hasConceptScore W4313349719C139563560 @default.
- W4313349719 hasConceptScore W4313349719C147483822 @default.
- W4313349719 hasConceptScore W4313349719C167672396 @default.
- W4313349719 hasConceptScore W4313349719C203014093 @default.
- W4313349719 hasConceptScore W4313349719C22222904 @default.
- W4313349719 hasConceptScore W4313349719C2776090121 @default.
- W4313349719 hasConceptScore W4313349719C2778607024 @default.
- W4313349719 hasConceptScore W4313349719C2780931953 @default.
- W4313349719 hasConceptScore W4313349719C37386791 @default.
- W4313349719 hasConceptScore W4313349719C67662055 @default.
- W4313349719 hasConceptScore W4313349719C86803240 @default.
- W4313349719 hasConceptScore W4313349719C8891405 @default.
- W4313349719 hasConceptScore W4313349719C95444343 @default.
- W4313349719 hasIssue "1_Supplement" @default.
- W4313349719 hasLocation W43133497191 @default.
- W4313349719 hasOpenAccess W4313349719 @default.
- W4313349719 hasPrimaryLocation W43133497191 @default.
- W4313349719 hasRelatedWork W1502561265 @default.
- W4313349719 hasRelatedWork W1933651519 @default.
- W4313349719 hasRelatedWork W1970027497 @default.
- W4313349719 hasRelatedWork W1975329879 @default.
- W4313349719 hasRelatedWork W2098344073 @default.
- W4313349719 hasRelatedWork W2158117877 @default.
- W4313349719 hasRelatedWork W2161368829 @default.
- W4313349719 hasRelatedWork W2336076392 @default.
- W4313349719 hasRelatedWork W2464823604 @default.
- W4313349719 hasRelatedWork W2793970569 @default.
- W4313349719 hasVolume "182" @default.
- W4313349719 isParatext "false" @default.
- W4313349719 isRetracted "false" @default.
- W4313349719 workType "article" @default.