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- W4313349720 abstract "Abstract Lymphopenia-induced proliferation (LIP) is a proliferative program initiated in response to T cell insufficiency caused by acute or chronic immunodepletion. Studies of lymphopenic mice have demonstrated that the cytokine IL-7 and TCR signaling are critical for LIP. We examined how these two factors impact T cell proliferation following transfer into moderately lymphopenic mice. We show here that moderate lymphopenia (~25% of WT lymphocytes) of IL-7Rα knock-in mutant (IL-7Rα449F) mice supports T cell proliferation, although with decreased frequency and kinetics compared to cells transferred to severely lymphopenic (5% of WT) IL-7Rα-/- hosts. Although previous studies have demonstrated that elevated IL-7 levels play an important role in LIP, IL-7 availability was not elevated in IL-7Rα449F mice. However, moderate lymphopenia increased access of transferred T cells to self-peptide presented on antigen presenting cells that can trigger TCR signaling and proliferation. Importantly, we did not detect significant changes in TCR Vβ usage of proliferated T cells recovered from either moderately or severely lymphopenic hosts. Our work demonstrates that polyclonal T cells retain a diverse TCR repertoire following proliferation mediated by either self-peptide/MHC interaction alone or in combination with IL-7, and that T cell reconstitution is most efficient in the presence of increased IL-7 availability." @default.
- W4313349720 created "2023-01-06" @default.
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- W4313349720 date "2011-04-01" @default.
- W4313349720 modified "2023-09-26" @default.
- W4313349720 title "Elevated IL-7 availability does not account for T cell proliferation in moderate lymphopenia. (104.11)" @default.
- W4313349720 doi "https://doi.org/10.4049/jimmunol.186.supp.104.11" @default.
- W4313349720 hasPublicationYear "2011" @default.
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