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- W4313349737 abstract "Abstract Respiratory virus infections are a major health problem in the elderly. This is due to declining immune responsiveness in the elderly and the development of CD8+ T cell clonal expansions (TCE) that perturb the memory T cell pool. We recently showed that TCE can arise over time from memory CD8+ T cells established by an acute respiratory viral infection. Virus-specific TCE are phenotypically identical to conventional memory cells and do not express the characteristics of exhausted cells. Since TCE can dominate the memory T cell pool, it is essential to determine the rate at which they develop, and their ability to mount a recall response to secondary pathogen challenge in vivo. In the current study, we developed an assay to detect developing TCE in a cohort of mice following Sendai virus infection and found a progressive increase in the appearance of TCE within the first year following infection. Using a dual adoptive transfer approach to address the recall potential of virus-specific TCE, we demonstrate that the majority of TCE examined are poorly responsive to a secondary infection. Taken together, the data suggest that the development of TCE is a common occurrence due to the progressive dysregulation of the virus-specific memory T cell pool with age, and many TCE are profoundly defective in their ability to mediate recall responses." @default.
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- W4313349737 date "2011-04-01" @default.
- W4313349737 modified "2023-09-26" @default.
- W4313349737 title "Virus-specific T cell clonal expansions can limit recall responses to secondary respiratory virus infections (104.4)" @default.
- W4313349737 doi "https://doi.org/10.4049/jimmunol.186.supp.104.4" @default.
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