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- W4313349809 abstract "Abstract Small ubiquitin-like modifier (SUMO) modification is an important regulatory mechanism underlying regulation of transcription factors in the immune system. However, whether it is involved in T cell receptor (TCR) proximal signaling is not known yet. Protein Kinase C-θ (PKCθ) plays an essential role in TCR/CD28-induced T cell activation. Here, we report that sumoylation is required for physiological activation of PKCθ in T cells. There are two sumoylation sites on PKCθ. Expressing a desumoylation mutant form of PKCθ(2KR) significantly impairs TCR/CD28-induced signaling and localization of PKCθ to the central supramolecular activation cluster (cSMAC), and results in inhibition of IL-2 production and T cell activation. Collectively, these results uncover a mechanism involved in TCR/CD28-triggered PKCθ activation and cSMAC localization, indicating the crosstalk between sumoylation and TCR proximal signaling pathways." @default.
- W4313349809 created "2023-01-06" @default.
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- W4313349809 date "2011-04-01" @default.
- W4313349809 modified "2023-10-14" @default.
- W4313349809 title "Sumoylation-dependent cSMAC localization of PKCθ is critical for T cell activation (109.25)" @default.
- W4313349809 doi "https://doi.org/10.4049/jimmunol.186.supp.109.25" @default.
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