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- W4313349816 abstract "Abstract The importance of regulatory T cells in immune tolerance is illustrated by the human immune dysregulatory disorder IPEX (immune dysregulation, polyendocrinopathy, enteropathy, Xlinked), caused by a lack of regulatory T cells due to decreased or absent expression of Foxp3. Although the majority of work on regulatory T cells has focused on their ability to suppress T cell responses, the development of significant autoantibody titers in patients with IPEX suggests regulatory T cells also contribute to the suppression of autoreactive B cells. Although these observations suggest that regulatory T cells have an important role in B cell biology, no studies have directly determined whether an absence of regulatory T cells impacts B cell development or B cell tolerance. Using a murine model of IPEX, harboring a mutation in the Foxp3 gene derived from a human IPEX patient, we show that B cell development is significantly altered in the absence of regulatory T cells. Furthermore, we identify a loss of B cell anergy as a likely mechanism to explain the production of autoantibodies and loss of tolerance that occurs in the absence of regulatory T cells. Our results suggest that regulatory T cells, by either direct, or indirect mechanisms, modulate B cell development and anergy." @default.
- W4313349816 created "2023-01-06" @default.
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- W4313349816 date "2010-04-01" @default.
- W4313349816 modified "2023-09-26" @default.
- W4313349816 title "Altered B cell Development and Anergy in the Absence of Foxp3 (143.20)" @default.
- W4313349816 doi "https://doi.org/10.4049/jimmunol.184.supp.143.20" @default.
- W4313349816 hasPublicationYear "2010" @default.
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