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- W4313349845 abstract "Abstract We have conducted clinical trials of adoptive γδ T cell therapy for the treatment of esophageal, colorectal, pancreatic and non-small-cell lung cancers, and cholangiocarcinoma. Patients received ≥1x109 γδ T cells every 2 weeks. These cells had been expanded ex vivo for 14 days by culture with zoledronate (5 μM) and IL-2 (1000 IU/ml). Infused γδ T cells gradually accumulated in patients’ peripheral blood and accounted for 10% of PBMC as late as 3 months after the final injection, even without IL-2 administration in vivo. These cells maintained the ability to release cytotoxic granules (detected by CD107 assay) and produce IFN-γ. To determine the factors contributing to γδ T cell survival in vivo, we investigated their expression of receptors for common γ chain (γc) family cytokines at the time of infusion. IL-2Rβ and γc, but not IL-7Rα, IL-15Rα or IL-21R, were present on these cells, and although the IL-2Rα was upregulated at the initiation of culture, it was only very weakly expressed at the time of transfer. When γδ T cells were maintained for longer periods in culture, IL-15 but not low dose IL-2 and IL-7 supported their survival. These results suggest that tissue-specific γc-dependent signals in response to IL-15 might affect the survival and function of infused γδ T cells, and hence materially influence the success of immunotherapy." @default.
- W4313349845 created "2023-01-06" @default.
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- W4313349845 date "2011-04-01" @default.
- W4313349845 modified "2023-10-01" @default.
- W4313349845 title "Requirements for common γ chain family cytokines for adoptively transferred γδ T cell function and homeostasis in vivo (156.19)" @default.
- W4313349845 doi "https://doi.org/10.4049/jimmunol.186.supp.156.19" @default.
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