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- W4313349870 abstract "Abstract Suppressor of cytokine signaling (SOCS) proteins have been identified as a negative feedback loop to cytokine signaling. Emerging evidence supports the potential role of SOCS in controlling immune disorders, but data regarding their expression in human T cells is still sparse. Interferon-β (IFN-β) is a broadly used and effective treatment for multiple sclerosis (MS), although mechanisms of actions are still incompletely resolved. We postulate that IFN-β mediates beneficial effects through the induction of SOCS in peripheral T cells. We first evaluated the expression of SOCS-1 and SOCS-3 at the mRNA (qRT-PCR) and protein levels (FACS, Western blot, immunocytochemistry) by human CD4 and CD8 T cells following IFN-β treatment. A rapid and significant increase of SOCS-1 and SOCS-3 was observed upon cytokine addition, especially in the CD8 T cell compartment. To mimic patients under IFN-β treatment, both T cell subsets were chronically exposed to physiological doses of IFN-β measured in treated patients. Only SOCS-1 but not SOCS-3 levels were elevated after each IFN-β re-exposure. These effects were more pronounced in CD8 T cells. Our preliminary data indicate different expression of SOCS in untreated and IFN-β-treated MS patients. Our results suggest that SOCS-1 contributes to the IFN-β-mediated beneficial effects in MS and that SOCS proteins are distinctly expressed in human T cell subsets. We are currently testing the functional impact of SOCS-1 on human T cell responses." @default.
- W4313349870 created "2023-01-06" @default.
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- W4313349870 date "2011-04-01" @default.
- W4313349870 modified "2023-10-01" @default.
- W4313349870 title "Human CD4 and CD8 T cells distinctly upregulate Suppressors of Cytokine Signaling 1 and 3 following Interferon-β treatment. (117.24)" @default.
- W4313349870 doi "https://doi.org/10.4049/jimmunol.186.supp.117.24" @default.
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