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- W4313349928 abstract "Abstract IFN-γ and perforin are important effector mechanisms used by CD8 T cells to clear virus-infected cells. Previous research has shown that either IFN-γ or pfp was non-essential for viral control after intranasal infection of mice with MHV-68. In this study, we use IFN/pfp double knockout mice to address if these two effector molecules play redundant roles in the control of acute infection with MHV-68 in Balb/C mice. Pfp KO mice and WT mice cleared infectious virus from the lungs, even following high dose infection. However IFN-γ KO and IFN/pfp DKO groups had higher virus titers in the lungs at day 10 post-infection and both groups had higher mortality rates. In IFN/pfp DKO mice, the virus titer and mortality rate were significant higher than IFN-γ KO mice, indicating a role for pfp in protection from disease. WT mice given IFN-γ blocking Ab also showed significant higher viral titers. In contrast, IFN-γ KO mice on a B6 background controlled respiratory infection comparably to WT mice. These data showed that pfp plays a redundant role in the control of virus replication but IFN-γ plays an essential role in Balb/C mice infected with MHV-68. We conclude that there is a marked strain-dependent difference in the effector mechanisms needed to control acute MHV-68 infection between B6 and Balb/C mice. In addition we show that immune therapy that re-establishes viral control after spontaneous reactivation in CD4-deficient mice depends upon pfp in B6 mice but IFN-γ in Balb/C mice." @default.
- W4313349928 created "2023-01-06" @default.
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- W4313349928 date "2010-04-01" @default.
- W4313349928 modified "2023-10-16" @default.
- W4313349928 title "Strain-dependent requirement for IFN-γ for respiratory control and immunotherapy in murine gammaherpesvirus infection (42.1)" @default.
- W4313349928 doi "https://doi.org/10.4049/jimmunol.184.supp.42.1" @default.
- W4313349928 hasPublicationYear "2010" @default.
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