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- W4313349969 abstract "Abstract Present day FLU vaccines have not changed since WWII, and depend upon the generation of neutralizing antibodies, which the virus readily escapes via mutations. Therefore, we focused on immunizing T cells with serologically non-cross reactive viral strains in a murine model. C57Bl/6 mice infected intra-nasally (i.n.) with H3N2-FLU were protected against a lethal challenge of H1N1-FLU. Cellular composition of the Broncho-Alveolar Lavage (BAL), lungs and mediastinal lymph nodes monitored by flow-cytometry 8 days after infection with H1N1-FLU yielded a vigorous cellular response, with a 2:1 ratio of CD8+ vs. CD4+ T cells in the BAL, and a high proportion of immunodominant nucleoprotein (NP) peptide-specific tetramer+ cells (~ 40%). By comparison, mice immunized i.n. with replication-incompetent adenovirus containing NP (10e7 pfu) were also protected against lethal challenge. Although the H3N2-FLU-infected control animals mobilized greater numbers of CD8+ T cells in the BAL 14d post H1N1 challenge, the vaccinated animals had 3X as many NP-specific tetramer+ T cells. Therefore, a non-replicating adenovirus vaccine can protect against a lethal challenge with a non-serologically cross-reactive flu strain, so that a “T cell vaccine” is effective in preventing symptomatic disease." @default.
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- W4313349969 date "2010-04-01" @default.
- W4313349969 modified "2023-09-26" @default.
- W4313349969 title "Towards the development of a universal T cell influenza (FLU) vaccine (52.10)" @default.
- W4313349969 doi "https://doi.org/10.4049/jimmunol.184.supp.52.10" @default.
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