Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313350008> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W4313350008 endingPage "114.10" @default.
- W4313350008 startingPage "114.10" @default.
- W4313350008 abstract "Abstract Inflammasomes play a crucial role in mediating innate and adaptive immunity against a variety of microbes and danger signals. However, regulatory mechanisms controlling inflammasome effector functions, specifically generation of the bioactive IL-1β in macrophages are not well studied. Pyrin-only proteins (POPs) modulate NF-κB signaling and inflammasome activation, thus restricting the magnitude of innate immune and inflammatory responses in humans. POP1 interferes with IKKα/β activation thus limiting NF-κB activity with no known effect on ASC-dependent inflammasomes. POP2, however, limits the transcriptional activity of NF-κB p65/RelA while also down-modulating the assembly of various ASC-dependent inflammasomes. Here we examine a third human POP, POP3, the product of an NLRP pseudogene with ubiquitous and inducible expression. Like POP1 and POP2, POP3 impairs NF-κB-mediated production of pro-inflammatory cytokines, but fails to inhibit ASC-dependent inflammasomes likely due to the absence of specific acidic residues within its first α helix. Despite high homology to POP2, POP3 is translocated to the nucleus in parallel with NF-kB and inhibits the transcriptional activity of nuclear NF-kB. Collectively, POP3 is a resurrected processed-pseudogene that in addition to other POPs likely represents a further level of control for NF-κB-dependent inflammatory responses" @default.
- W4313350008 created "2023-01-06" @default.
- W4313350008 creator A5025658229 @default.
- W4313350008 creator A5039189050 @default.
- W4313350008 creator A5081886501 @default.
- W4313350008 date "2012-05-01" @default.
- W4313350008 modified "2023-10-01" @default.
- W4313350008 title "The CLRX.1/NOD24 pseudogene codes a functional NF-κB regulator, Pyrin-only protein 3 (POP3) (114.10)" @default.
- W4313350008 doi "https://doi.org/10.4049/jimmunol.188.supp.114.10" @default.
- W4313350008 hasPublicationYear "2012" @default.
- W4313350008 type Work @default.
- W4313350008 citedByCount "0" @default.
- W4313350008 crossrefType "journal-article" @default.
- W4313350008 hasAuthorship W4313350008A5025658229 @default.
- W4313350008 hasAuthorship W4313350008A5039189050 @default.
- W4313350008 hasAuthorship W4313350008A5081886501 @default.
- W4313350008 hasConcept C104317684 @default.
- W4313350008 hasConcept C136449434 @default.
- W4313350008 hasConcept C139174496 @default.
- W4313350008 hasConcept C141231307 @default.
- W4313350008 hasConcept C185592680 @default.
- W4313350008 hasConcept C203014093 @default.
- W4313350008 hasConcept C2776914184 @default.
- W4313350008 hasConcept C2777209026 @default.
- W4313350008 hasConcept C2777730290 @default.
- W4313350008 hasConcept C34957205 @default.
- W4313350008 hasConcept C51785407 @default.
- W4313350008 hasConcept C54355233 @default.
- W4313350008 hasConcept C62478195 @default.
- W4313350008 hasConcept C6929976 @default.
- W4313350008 hasConcept C86803240 @default.
- W4313350008 hasConcept C8891405 @default.
- W4313350008 hasConcept C95444343 @default.
- W4313350008 hasConceptScore W4313350008C104317684 @default.
- W4313350008 hasConceptScore W4313350008C136449434 @default.
- W4313350008 hasConceptScore W4313350008C139174496 @default.
- W4313350008 hasConceptScore W4313350008C141231307 @default.
- W4313350008 hasConceptScore W4313350008C185592680 @default.
- W4313350008 hasConceptScore W4313350008C203014093 @default.
- W4313350008 hasConceptScore W4313350008C2776914184 @default.
- W4313350008 hasConceptScore W4313350008C2777209026 @default.
- W4313350008 hasConceptScore W4313350008C2777730290 @default.
- W4313350008 hasConceptScore W4313350008C34957205 @default.
- W4313350008 hasConceptScore W4313350008C51785407 @default.
- W4313350008 hasConceptScore W4313350008C54355233 @default.
- W4313350008 hasConceptScore W4313350008C62478195 @default.
- W4313350008 hasConceptScore W4313350008C6929976 @default.
- W4313350008 hasConceptScore W4313350008C86803240 @default.
- W4313350008 hasConceptScore W4313350008C8891405 @default.
- W4313350008 hasConceptScore W4313350008C95444343 @default.
- W4313350008 hasIssue "1_Supplement" @default.
- W4313350008 hasLocation W43133500081 @default.
- W4313350008 hasOpenAccess W4313350008 @default.
- W4313350008 hasPrimaryLocation W43133500081 @default.
- W4313350008 hasRelatedWork W2037270713 @default.
- W4313350008 hasRelatedWork W2059381041 @default.
- W4313350008 hasRelatedWork W2070451088 @default.
- W4313350008 hasRelatedWork W2520706715 @default.
- W4313350008 hasRelatedWork W2919321004 @default.
- W4313350008 hasRelatedWork W4240510062 @default.
- W4313350008 hasRelatedWork W4254536103 @default.
- W4313350008 hasRelatedWork W4313350008 @default.
- W4313350008 hasRelatedWork W989578363 @default.
- W4313350008 hasRelatedWork W1492686073 @default.
- W4313350008 hasVolume "188" @default.
- W4313350008 isParatext "false" @default.
- W4313350008 isRetracted "false" @default.
- W4313350008 workType "article" @default.