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- W4313350013 abstract "Abstract Plasmacytoid dendritic cells (pDC) are specialized dendritic cells, also known as IFN-α producing cells. pDC are key inducers of immune responses upon viral infections; the environment although modulate their phenotype and functions. We have shown that cord blood (CB) pDC are unable to produce IFN-α after stimulation while they retain the capacity to maturate in antigen presenting cells. To get insights into the mechanisms of pDC regulation in CB, we first investigated the levels of immune regulators secreted by the placenta in CB. We show that progesterone (PG), IL-10 and TGF-β are present at high levels in CB as compared to adult blood. Using in vitro differentiated pDCs we analysed the effect of these molecules, separately or in combination, on pDC differentiation and activation. We reveal that physiological concentrations of these three factors individually have low impact on pDCs while in combination they inhibit pDC differentiation and IFN-α production. Higher concentrations of PG, IL-10 or TGF-β are also able to inhibit IFN-α production, but these conditions are not relevant to physiological levels in CB. Our results therefore shed new light on the synergy of immune regulators secreted by the placenta that have an impact on foetal and neonatal immune responses." @default.
- W4313350013 created "2023-01-06" @default.
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- W4313350013 date "2011-04-01" @default.
- W4313350013 modified "2023-10-01" @default.
- W4313350013 title "Progesterone, IL-10 and TGF-β act in synergy to impair plasmacytoid dendritic cell functions in cord blood (57.19)" @default.
- W4313350013 doi "https://doi.org/10.4049/jimmunol.186.supp.57.19" @default.
- W4313350013 hasPublicationYear "2011" @default.
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