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- W4313350018 abstract "Abstract RIG-I like receptors (RLR) are key cytoplasmic receptors to recognize viral RNA, and induce type I interferons via transcription factors such as IRF3 and NF-κB. Here we describe a novel signaling pathway involving PKCα, HDAC6 and β-catenin, which is essential for IRF3-mediated gene induction after virus infection. Stable knockdown of PKCα in various human cell lines inhibited Sendai virus-mediated IFN induction and enhanced virus replication. Sendai virus infection activated PKCα, which enhanced HDAC6 activity in a signal-dependent manner. HDAC6 physically interacted with PKCα and virus infection increased the deacetylation activity of HDAC6, which was absent in PKCα knockdown cells. HDAC6-mediated deacetylation of β-catenin enhanced its nuclear translocation and promoter binding, which was also attenuated in PKCα knockdown cells. We show that in the absence of PKCα/HDAC6-mediated β-catenin nuclear translocation, IRF3, although activated, does not bind to its promoter and is unable to support transcription." @default.
- W4313350018 created "2023-01-06" @default.
- W4313350018 creator A5052471392 @default.
- W4313350018 creator A5055690600 @default.
- W4313350018 date "2011-04-01" @default.
- W4313350018 modified "2023-10-14" @default.
- W4313350018 title "The Protein Kinase C alpha regulates RIG-I mediated IRF3 activation through HDAC6 and beta-catenin (158.18)" @default.
- W4313350018 doi "https://doi.org/10.4049/jimmunol.186.supp.158.18" @default.
- W4313350018 hasPublicationYear "2011" @default.
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