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- W4313350026 abstract "Abstract CD1d expressing cells present lipid antigen to CD1d-restricted natural killer T (NKT) cells, which play an important role in immune regulation and tumor rejection. Lymphoid enhancer-binding factor-1 (LEF-1) is one of the regulators of the Wnt signaling pathway, which is a powerful regulator in cellular growth, differentiation, and transformation. There is little evidence connecting Wnt signaling to CD1d expression. In this study, we have identified LEF-1 as a regulator of the expression of the gene encoding the human CD1d molecule (CD1D). We found that LEF-1 binds specifically to the CD1D promoter. Over-expression of LEF-1 in K562 or Jurkat cells suppresses CD1D promoter activity and down regulates endogenous CD1D transcripts, whereas knockdown of LEF-1 using LEF-1-specific siRNA increases CD1D transcripts in K562 and Jurkat cells but different levels of surface CD1d on these two cell types. Chromatin immunoprecipitation showed that the endogenous LEF-1 factor is situated at the CD1D promoter and interacts with histone deacetylase-1 to facilitate the transcriptional repressor activity. Knockdown of LEF-1 using siRNA potentiates an acetylation state of histone H3/H4, supporting that LEF-1 acts as a transcriptional repressor for CD1D gene. Our finding links LEF-1 to CD1D and suggests a role of Wnt signaling in the regulation of human CD1D gene." @default.
- W4313350026 created "2023-01-06" @default.
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- W4313350026 date "2010-04-01" @default.
- W4313350026 modified "2023-10-17" @default.
- W4313350026 title "Human CD1D gene expression is regulated by LEF-1 through distal promoter regulatory elements (95.4)" @default.
- W4313350026 doi "https://doi.org/10.4049/jimmunol.184.supp.95.4" @default.
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