Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313350069> ?p ?o ?g. }
Showing items 1 to 66 of
66
with 100 items per page.
- W4313350069 endingPage "101.34" @default.
- W4313350069 startingPage "101.34" @default.
- W4313350069 abstract "Abstract IL-1β has been shown to play a role in several inflammatory disorders including mouse experimental autoimmune encephalomyelitis (EAE). We found that mice deficient for the apoptosis-associated speck-like protein containing a caspase recruitment domain, or ASC, did not develop EAE following immunization with MOG in CFA and pertussis toxin (PT). Autoreactive T cells were primed in wild-type (WT) and ASC-/- mice but expanded poorly in ASC-/- mice with reduced capacity to produce simultaneously several inflammatory cytokines, such as IL-17, IL-22, IFNγ, and GM-CSF. The induction of these T cells in WT mice but not ASC-/- mice was dependent on the presence of PT. PT was found to induce IL-1β secretion from antigen-presenting cells, such as DCs and microglia. These data suggest that the disease-inducing effect of PT may be due to its ability to induce production of IL-1β which in turn triggers differentiation of pathogenic multifunctional T cells. In addition to its effect in the induction phase, we are testing whether IL-1β, or other inflammasome-related cytokines, may be required in the effector phases of EAE. We found that ASC-/- mice are resistant to passive EAE induction. In addition, bone marrow chimera experiments of mice transplanted with bone marrow cells from WT mice or ASC-/- mice, showed that IL-1β production by microglial cells, CNS-resident myeloid cells and CNS-migrating inflammatory monocytes is important for EAE pathogenesis." @default.
- W4313350069 created "2023-01-06" @default.
- W4313350069 creator A5039809341 @default.
- W4313350069 creator A5047171254 @default.
- W4313350069 creator A5059965999 @default.
- W4313350069 creator A5064962884 @default.
- W4313350069 creator A5080711784 @default.
- W4313350069 date "2011-04-01" @default.
- W4313350069 modified "2023-10-01" @default.
- W4313350069 title "On the role of IL-1β and CNS myeloid cells in EAE pathogenesis (101.34)" @default.
- W4313350069 doi "https://doi.org/10.4049/jimmunol.186.supp.101.34" @default.
- W4313350069 hasPublicationYear "2011" @default.
- W4313350069 type Work @default.
- W4313350069 citedByCount "0" @default.
- W4313350069 crossrefType "journal-article" @default.
- W4313350069 hasAuthorship W4313350069A5039809341 @default.
- W4313350069 hasAuthorship W4313350069A5047171254 @default.
- W4313350069 hasAuthorship W4313350069A5059965999 @default.
- W4313350069 hasAuthorship W4313350069A5064962884 @default.
- W4313350069 hasAuthorship W4313350069A5080711784 @default.
- W4313350069 hasConcept C203014093 @default.
- W4313350069 hasConcept C2776914184 @default.
- W4313350069 hasConcept C2777209026 @default.
- W4313350069 hasConcept C2778486448 @default.
- W4313350069 hasConcept C2779830541 @default.
- W4313350069 hasConcept C2780007613 @default.
- W4313350069 hasConcept C2780942790 @default.
- W4313350069 hasConcept C49773422 @default.
- W4313350069 hasConcept C62478195 @default.
- W4313350069 hasConcept C80631254 @default.
- W4313350069 hasConcept C86803240 @default.
- W4313350069 hasConcept C8891405 @default.
- W4313350069 hasConcept C95444343 @default.
- W4313350069 hasConceptScore W4313350069C203014093 @default.
- W4313350069 hasConceptScore W4313350069C2776914184 @default.
- W4313350069 hasConceptScore W4313350069C2777209026 @default.
- W4313350069 hasConceptScore W4313350069C2778486448 @default.
- W4313350069 hasConceptScore W4313350069C2779830541 @default.
- W4313350069 hasConceptScore W4313350069C2780007613 @default.
- W4313350069 hasConceptScore W4313350069C2780942790 @default.
- W4313350069 hasConceptScore W4313350069C49773422 @default.
- W4313350069 hasConceptScore W4313350069C62478195 @default.
- W4313350069 hasConceptScore W4313350069C80631254 @default.
- W4313350069 hasConceptScore W4313350069C86803240 @default.
- W4313350069 hasConceptScore W4313350069C8891405 @default.
- W4313350069 hasConceptScore W4313350069C95444343 @default.
- W4313350069 hasIssue "1_Supplement" @default.
- W4313350069 hasLocation W43133500691 @default.
- W4313350069 hasOpenAccess W4313350069 @default.
- W4313350069 hasPrimaryLocation W43133500691 @default.
- W4313350069 hasRelatedWork W1964368494 @default.
- W4313350069 hasRelatedWork W1994505240 @default.
- W4313350069 hasRelatedWork W2017942158 @default.
- W4313350069 hasRelatedWork W2063758367 @default.
- W4313350069 hasRelatedWork W241133616 @default.
- W4313350069 hasRelatedWork W2899252087 @default.
- W4313350069 hasRelatedWork W3025918268 @default.
- W4313350069 hasRelatedWork W3135533983 @default.
- W4313350069 hasRelatedWork W3198360346 @default.
- W4313350069 hasRelatedWork W4200373940 @default.
- W4313350069 hasVolume "186" @default.
- W4313350069 isParatext "false" @default.
- W4313350069 isRetracted "false" @default.
- W4313350069 workType "article" @default.