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- W4313350073 abstract "Abstract Helper T cell (Th cell) differentiation is precisely regulated by thousands of genes at different stages. In the present study, we demonstrate that Dec2, a transcription factor belonging to the bHLH (basic helix-loop-helix) superfamily, is progressively induced during the course of Th2 differentiation, especially at the late stage. The up-regulated Dec2 can strongly promote Th2 development under Th2-inducing conditions, as evidenced by retrovirus-mediated gene transfer or transgenic manipulation. In addition, an enhancement of Th2 responses is also detectable in Dec2 transgenic mice in vivo. Conversely, RNAi-mediated suppression of endogenous Dec2 could attenuate Th2 differentiation. Finally, we show that the enhanced Th2 development is at least in part due to substantial up-regulation of CD25 expression elicited by Dec2, thereby resulting in hyperresponsiveness to IL-2 stimulation." @default.
- W4313350073 created "2023-01-06" @default.
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- W4313350073 date "2010-04-01" @default.
- W4313350073 modified "2023-09-25" @default.
- W4313350073 title "Dec2 promotes Th2 cell differentiation by enhancing IL-2R signaling (99.6)" @default.
- W4313350073 doi "https://doi.org/10.4049/jimmunol.184.supp.99.6" @default.
- W4313350073 hasPublicationYear "2010" @default.
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