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- W4313350075 startingPage "164.4" @default.
- W4313350075 abstract "Abstract Microglia, when induced to an alternatively activated state, play important roles in cellular immunity and tissue repair. In experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS), alternatively activated microglia (aaMG) exhibit a reduced inflammatory response, confined phagocytosis, and promoted functional recovery of myelin, which together can alleviate EAE. Here we investigated the effect of baicalein (BA), a potent neuroprotective compound, on EAE. BA administration significantly attenuated EAE severity by reducing both inflammatory infiltration and demyelination in the central nervous system. The inhibitory effect of BA was not caused by impaired T cell responses in the periphery. Interestingly, we observed that BA significantly increased the expression of alternative activation-associated genes in microglia. Furthermore, we showed that induction of aaMG by BA is attributable to increased peroxisome proliferator-activated receptor (PPAR)-β transcriptional activity through activation of the PI3K signal. Importantly, BA-induced aaMG showed significant preventive effects in EAE mice. Taken together, these data demonstrate that BA has a potent inductive effect on aaMG through PPAR-β expression in microglia that mediated by PI3K activation, which led to reduced disease severity during EAE disease process. This provides novel insights into a therapeutic modality in MS." @default.
- W4313350075 created "2023-01-06" @default.
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- W4313350075 date "2011-04-01" @default.
- W4313350075 modified "2023-10-01" @default.
- W4313350075 title "Baicalein promotes PPAR-β-mediated alternative activation of microglia in alleviating experimental autoimmune encephalomyelitis (164.4)" @default.
- W4313350075 doi "https://doi.org/10.4049/jimmunol.186.supp.164.4" @default.
- W4313350075 hasPublicationYear "2011" @default.
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