Matches in SemOpenAlex for { <https://semopenalex.org/work/W4313350078> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W4313350078 endingPage "55.11" @default.
- W4313350078 startingPage "55.11" @default.
- W4313350078 abstract "Abstract Allergic asthma severity may be associated with IgE levels. We have shown that beta-2 adrenergic receptor (β2AR) engagement on CD40L/IL-4-primed B cells increases the level of IgE produced per cell, without affecting class switch recombination. β2AR agonists alleviate bronchoconstriction by targeting the β2AR expressed on bronchiolar smooth muscle cells to trigger airway relaxation, but these drugs also target the β2AR on primed B cells, potentially producing an IgE effect that may be counterproductive to the drugs intended use. We reported that surface CD23 expression remained constant on primed B cells exposed to a β2AR agonist, while CD23 mRNA, total CD23 protein, and soluble CD23 (sCD23) increased. Thus, if sCD23 positively regulates IgE production, an increase due to β2AR engagement may worsen bronchoconstriction, albeit relieving it in the short term. We hypothesized that the primary sheddase of CD23, ADAM10, is regulated by β2AR engagement on a primed B cell. Although we found that β2AR engagement was unable to affect the level of ADAM10 protein or mRNA produced compared to primed cells alone, our recent data indicated that the β2AR-induced increase in CD23 shedding may be mediated by increased localization of mature ADAM10 with CD23. Thus, ADAM10 may be a molecular target that can be blocked during β2AR drug therapy to prevent increased sCD23 and IgE, which may counteract the therapeutic bronchorelaxation." @default.
- W4313350078 created "2023-01-06" @default.
- W4313350078 creator A5014930847 @default.
- W4313350078 creator A5049351821 @default.
- W4313350078 date "2011-04-01" @default.
- W4313350078 modified "2023-09-23" @default.
- W4313350078 title "Cleavage of CD23 by ADAM proteins is regulated by beta-2 adrenergic receptor engagement on primed B cells (55.11)" @default.
- W4313350078 doi "https://doi.org/10.4049/jimmunol.186.supp.55.11" @default.
- W4313350078 hasPublicationYear "2011" @default.
- W4313350078 type Work @default.
- W4313350078 citedByCount "0" @default.
- W4313350078 crossrefType "journal-article" @default.
- W4313350078 hasAuthorship W4313350078A5014930847 @default.
- W4313350078 hasAuthorship W4313350078A5049351821 @default.
- W4313350078 hasConcept C104317684 @default.
- W4313350078 hasConcept C105580179 @default.
- W4313350078 hasConcept C141105273 @default.
- W4313350078 hasConcept C153911025 @default.
- W4313350078 hasConcept C159654299 @default.
- W4313350078 hasConcept C170493617 @default.
- W4313350078 hasConcept C181199279 @default.
- W4313350078 hasConcept C185592680 @default.
- W4313350078 hasConcept C203014093 @default.
- W4313350078 hasConcept C2776042228 @default.
- W4313350078 hasConcept C2778259572 @default.
- W4313350078 hasConcept C2778715156 @default.
- W4313350078 hasConcept C2780769369 @default.
- W4313350078 hasConcept C34814297 @default.
- W4313350078 hasConcept C54355233 @default.
- W4313350078 hasConcept C55493867 @default.
- W4313350078 hasConcept C55728118 @default.
- W4313350078 hasConcept C86803240 @default.
- W4313350078 hasConcept C95444343 @default.
- W4313350078 hasConceptScore W4313350078C104317684 @default.
- W4313350078 hasConceptScore W4313350078C105580179 @default.
- W4313350078 hasConceptScore W4313350078C141105273 @default.
- W4313350078 hasConceptScore W4313350078C153911025 @default.
- W4313350078 hasConceptScore W4313350078C159654299 @default.
- W4313350078 hasConceptScore W4313350078C170493617 @default.
- W4313350078 hasConceptScore W4313350078C181199279 @default.
- W4313350078 hasConceptScore W4313350078C185592680 @default.
- W4313350078 hasConceptScore W4313350078C203014093 @default.
- W4313350078 hasConceptScore W4313350078C2776042228 @default.
- W4313350078 hasConceptScore W4313350078C2778259572 @default.
- W4313350078 hasConceptScore W4313350078C2778715156 @default.
- W4313350078 hasConceptScore W4313350078C2780769369 @default.
- W4313350078 hasConceptScore W4313350078C34814297 @default.
- W4313350078 hasConceptScore W4313350078C54355233 @default.
- W4313350078 hasConceptScore W4313350078C55493867 @default.
- W4313350078 hasConceptScore W4313350078C55728118 @default.
- W4313350078 hasConceptScore W4313350078C86803240 @default.
- W4313350078 hasConceptScore W4313350078C95444343 @default.
- W4313350078 hasIssue "1_Supplement" @default.
- W4313350078 hasLocation W43133500781 @default.
- W4313350078 hasOpenAccess W4313350078 @default.
- W4313350078 hasPrimaryLocation W43133500781 @default.
- W4313350078 hasRelatedWork W1964666103 @default.
- W4313350078 hasRelatedWork W1997877825 @default.
- W4313350078 hasRelatedWork W2047494851 @default.
- W4313350078 hasRelatedWork W2072688415 @default.
- W4313350078 hasRelatedWork W2115707856 @default.
- W4313350078 hasRelatedWork W2418247518 @default.
- W4313350078 hasRelatedWork W2472497537 @default.
- W4313350078 hasRelatedWork W4288752181 @default.
- W4313350078 hasRelatedWork W4313350078 @default.
- W4313350078 hasRelatedWork W65306418 @default.
- W4313350078 hasVolume "186" @default.
- W4313350078 isParatext "false" @default.
- W4313350078 isRetracted "false" @default.
- W4313350078 workType "article" @default.